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1 Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA
2 Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
* To whom correspondence should be addressed. E-mail: ahajnal{at}psu.edu.
The Otsuka Long Evans Tokushima Fatty (OLETF) rats lack the CCK-1 receptor, are hyperphagic, progressively become obese, and develop type-2 diabetes. We recently demonstrated an increased preference for both real and sham feeding of sucrose in this strain suggesting altered orosensory sensitivity. To investigate taste functions, we used an automated gustometer with 10-sec access to different concentrations of various sapid stimuli. Tests were repeated at 10 and 18 weeks of age to assess the early and advanced stages of pre-diabetes, respectively. Compared with age-matched, non-mutant controls, the OLETF rats showed higher avidity for sucrose at both ages. This difference increased as a function of age and tastant concentration. An exaggerated response also occurred for saccharin, alanine, and fructose, but not for Polycose. Similarly, OLETF rats consumed monosodium-glutamate more at the lower concentrations compared with controls, an effect that age also accentuated. In contrast, there was no statistical strain or age differences in responses to NaCl, MgCl2, citric acid, quinine-HCl and the trigeminal stimulus, capsaicin. These findings demonstrate that compared to controls, OLETF rats differ in their gustatory functions with an overall augmented sensitivity for sweet that progresses during pre-diabetes. This effect explains their overconsumption of sweet solutions and may contribute to the overall hyperphagia and obesity in this strain.
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