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Am J Physiol Regul Integr Comp Physiol (September 27, 2002). doi:10.1152/ajpregu.00424.2002
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Articles in PresS, published online ahead of print September 26, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00424.2002
Submitted on July 16, 2002
Accepted on August 22, 2002

Photoperiodic effects on gene expression for neuropeptide Y, agouti related peptide, melanin concentrating hormone, orexin and leptin receptor in the hypothalamus of the soay ram; relationship to voluntary food intake

Iain J Clarke1*, Alexandra Rao1, Yves Chilliard2, Carole Delavaud2, and Gerald A Lincoln3

1 Neuroendocrinology, Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
2 Unite de Recherche sur les Herbivores, INRA-Theix, St-Genes Champanelle, France
3 MRC Human Reproductive Sciences Unit Centre for Reproductive Biology, The University of Edinburgh, Edinburgh, UK

* To whom correspondence should be addressed. E-mail: iain.clarke{at}med.monash.edu.au.

Relationship between voluntary food intake (VFI) and gene expression for appetite regulating peptides was examined in the brains of Soay rams under contrasting photoperiods. Two groups (n=8) were subjected to alternating long-day (LD) and short-day (SD) photoperiods for 42 weeks to entrain long-term cycles in VFI. Five animals from each group were killed 18 weeks into LD or SD and the brains were collected for in situ hybridisation studies. VFI was 4-fold higher under LD compared to SD. Bodyweight, abdominal fat or plasma leptin levels were similar under LD and SD. LD animals were in positive energy balance and sexually inactive and SD animals were in negative energy balance and sexually active. Neuropeptide Y (NPY) mRNA levels were higher in the arcuate nucleus (ARC) under LD and pro-opiomelanocortin expression was lower under LD. Leptin receptor (Ob-Rb) was higher in the ARC under LD. We conclude that photoperiod-induced increase in VFI correlates with expression of NPY, but not with expression of genes for other orexigenic peptides. Ob-Rb gene expression is regulated by photoperiod.




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