AJP - Regu AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (September 21, 2001). doi:10.1152/ajpregu.00470.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
281/5/R1362    most recent
00470.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brown, R.
Right arrow Articles by Persson, A. E. G
Right arrow Search for Related Content
PubMed
Right arrow Articles by Brown, R.
Right arrow Articles by Persson, A. E. G

Articles in PresS, published online ahead of print September 21, 2001
Am J Physiol Regu Physiol, 10.1152/ajpregu.00470.2001
Submitted on August 3, 2001
Accepted on August 9, 2001

Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor deficient mice

Russell Brown1, Anna Ollerstam1, Bjorn Johansson2, Ole Skott3, Samuel Gebre-Medhin4, Bertil Fredholm2, and A. Erik G Persson1*

1 Medical Cell Biology, Uppsala University, Uppsala, Sweden
2 Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
3 Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
4 Medical Biochemistry, Goteborg University, Goteborg, Sweden

* To whom correspondence should be addressed. E-mail: anna.ollerstam{at}bmc.uu.se.

The hypothesis that adenosine acting on adenosine A1 receptors (A1R) regulates several renal functions and mediates tubuloglomerular feedback (TGF) was examined using A1R knockout mice. We anaesthetized knockout, wild-type and heterozygote mice and measured glomerular filtration rate, TGF response using the stop-flow pressure (Psf) technique and plasma renin concentration. The A1R knockout mice had an increased blood pressure compared to wild-type and heterozygote mice. Glomerular filtration rate was similar in all genotypes. Proximal tubular Psf was decreased from 36.7±1.2 to 25.3±1.6 mmHg in the A1R+/+ mice and from 38.1±1.0 to 27.4±1.1 mmHg in A1R+/- mice in response to an increase in tubular flow rate frpm 0 to 35 nl min-1. This response was abolished in the homozygous A1R -/- mice (from 39.1±4.1 to 39.2±4.5 mmHg). Plasma renin activity was significantly greater in the A1R knockout mice (74.2±14.3 mGU ml-1) mice compared to the wild type and A1R+/- mice (36.3±8.5 and 34.1±9.6 mGU ml-1), respectively. The results demonstrate that adenosine acting on A1R is required for TGF and modulates renin release.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Oppermann, Y. Qin, E. Y. Lai, C. Eisner, L. Li, Y. Huang, D. Mizel, J. Fryc, C. S. Wilcox, J. Briggs, et al.
Enhanced tubuloglomerular feedback in mice with vascular overexpression of A1 adenosine receptors
Am J Physiol Renal Physiol, November 1, 2009; 297(5): F1256 - F1264.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
J. Peti-Peterdi, I. Toma, A. Sipos, and S. L. Vargas
Multiphoton Imaging of Renal Regulatory Mechanisms
Physiology, April 1, 2009; 24(2): 88 - 96.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. Carlstrom and A. E. G. Persson
Important Role of NAD(P)H Oxidase 2 in the Regulation of the Tubuloglomerular Feedback
Hypertension, March 1, 2009; 53(3): 456 - 457.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Carlstrom, E. Y. Lai, Z. Ma, A. Patzak, R. D. Brown, and A. E. G. Persson
Role of NOX2 in the regulation of afferent arteriole responsiveness
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R72 - R79.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. J. Turner, R. D. Brown, M. Carlstrom, K. J. Gibson, and A. E. G. Persson
Mechanisms of neonatal increase in glomerular filtration rate
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R916 - R921.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. Castrop
Modulation of adenosine receptor expression in the proximal tubule: a novel adaptive mechanism to regulate renal salt and water metabolism
Am J Physiol Renal Physiol, July 1, 2008; 295(1): F35 - F36.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Oppermann, D. J. Friedman, R. Faulhaber-Walter, D. Mizel, H. Castrop, K. Enjyoji, S. C. Robson, and J. Schnermann
Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice
Am J Physiol Renal Physiol, April 1, 2008; 294(4): F965 - F970.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
V. Vallon, C. Miracle, and S. Thomson
Adenosine and kidney function: Potential implications in patients with heart failure
Eur J Heart Fail, February 1, 2008; 10(2): 176 - 187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Vallon
P2 receptors in the regulation of renal transport mechanisms
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F10 - F27.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Patzak, E. Y. Lai, M. Fahling, M. Sendeski, P. Martinka, P. B. Persson, and A. E. G. Persson
Adenosine enhances long term the contractile response to angiotensin II in afferent arterioles
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2232 - R2242.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Just and W. J. Arendshorst
A novel mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1489 - F1500.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
G. T. C. Wong and M. G. Irwin
Contrast-induced nephropathy
Br. J. Anaesth., October 1, 2007; 99(4): 474 - 483.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M.-G. Feng and L. G. Navar
Adenosine A2 Receptor Activation Attenuates Afferent Arteriolar Autoregulation During Adenosine Receptor Saturation in Rats
Hypertension, October 1, 2007; 50(4): 744 - 749.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
Z. Guan, D. A. Osmond, and E. W. Inscho
Purinoceptors in the Kidney
Experimental Biology and Medicine, June 1, 2007; 232(6): 715 - 726.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Just
Mechanisms of renal blood flow autoregulation: dynamics and contributions
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R1 - R17.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Y. Lai, P. Martinka, M. Fahling, R. Mrowka, A. Steege, A. Gericke, M. Sendeski, P.B. Persson, A. E. G. Persson, and A. Patzak
Adenosine Restores Angiotensin II-Induced Contractions by Receptor-Independent Enhancement of Calcium Sensitivity in Renal Arterioles
Circ. Res., November 10, 2006; 99(10): 1117 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Y. Huang, V. Vallon, H. Zimmermann, P. Koszalka, J. Schrader, and H. Osswald
Ecto-5'-nucleotidase (cd73)-dependent and -independent generation of adenosine participates in the mediation of tubuloglomerular feedback in vivo
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F282 - F288.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
V. Vallon, B. Muhlbauer, and H. Osswald
Adenosine and kidney function.
Physiol Rev, July 1, 2006; 86(3): 901 - 940.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. D. Brown, P. Thoren, A. Steege, R. Mrowka, J. Sallstrom, O. Skott, B. B. Fredholm, and A. E. G. Persson
Influence of the adenosine A1 receptor on blood pressure regulation and renin release
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1324 - R1329.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. M. Kim, D. Mizel, Y. G. Huang, J. P. Briggs, and J. Schnermann
Adenosine as a mediator of macula densa-dependent inhibition of renin secretion
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1016 - F1023.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Takenaka, H. Okada, Y. Kanno, T. Inoue, M. Ryuzaki, H. Nakamoto, H. Kawachi, F. Shimizu, and H. Suzuki
Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats
Am J Physiol Renal Physiol, April 1, 2006; 290(4): F844 - F853.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Hashimoto, Y. Huang, J. Briggs, and J. Schnermann
Reduced autoregulatory effectiveness in adenosine 1 receptor-deficient mice
Am J Physiol Renal Physiol, April 1, 2006; 290(4): F888 - F891.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. R. Lankford, J.-N. Yang, R. Rose'Meyer, B. A. French, G. P. Matherne, B. B. Fredholm, and Z. Yang
Effect of modulating cardiac A1 adenosine receptor expression on protection with ischemic preconditioning
Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1469 - H1473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Nishiyama, K. E. Jackson, D. S. A. Majid, M. Rahman, and L. G. Navar
Renal interstitial fluid ATP responses to arterial pressure and tubuloglomerular feedback activation during calcium channel blockade
Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H772 - H777.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. K. Jackson
Putting the Brakes on Renin Release: Role of the A1 Receptor
Hypertension, October 1, 2005; 46(4): 649 - 651.
[Full Text] [PDF]

Home page
 HypertensionHome page
F. Schweda, F. Segerer, H. Castrop, J. Schnermann, and A. Kurtz
Blood Pressure-Dependent Inhibition of Renin Secretion Requires A1 Adenosine Receptors
Hypertension, October 1, 2005; 46(4): 780 - 786.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. L. Liclican, J. C. McGiff, P. L. Pedraza, N. R. Ferreri, J. R. Falck, and M. A. Carroll
Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids
Am J Physiol Renal Physiol, August 1, 2005; 289(2): F386 - F392.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. K. Kishore, J. Isaac, M. Fausther, S. R. Tripp, H. Shi, P. S. Gill, N. Braun, H. Zimmermann, J. Sevigny, and S. C. Robson
Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling
Am J Physiol Renal Physiol, May 1, 2005; 288(5): F1032 - F1043.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
P. Komlosi, A. Fintha, and P. D. Bell
Renal Cell-to-Cell Communication via Extracellular ATP
Physiology, April 1, 2005; 20(2): 86 - 90.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
S. K. Thukral, P. J. Nordone, R. Hu, L. Sullivan, E. Galambos, V. D. Fitzpatrick, L. Healy, M. B. Bass, M. E. Cosenza, and C. A. Afshari
Prediction of Nephrotoxicant Action and Identification of Candidate Toxicity-Related Biomarkers
Toxicol Pathol, April 1, 2005; 33(3): 343 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. J. Welch
Role of renal tissue angiotensin II in proximal tubule function
Am J Physiol Renal Physiol, March 1, 2005; 288(3): F443 - F444.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Fraser, P. Mount, R. Hill, V. Levidiotis, F. Katsis, D. Stapleton, B. E. Kemp, and D. A. Power
Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality
Am J Physiol Renal Physiol, March 1, 2005; 288(3): F578 - F586.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. Komlosi, J. Peti-Peterdi, A. L. Fuson, A. Fintha, L. Rosivall, and P. D. Bell
Macula densa basolateral ATP release is regulated by luminal [NaCl] and dietary salt intake
Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1054 - F1058.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Z. Qi, I. Whitt, A. Mehta, J. Jin, M. Zhao, R. C. Harris, A. B. Fogo, and M. D. Breyer
Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance
Am J Physiol Renal Physiol, March 1, 2004; 286(3): F590 - F596.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
Y. Liao, S. Takashima, Y. Asano, M. Asakura, A. Ogai, Y. Shintani, T. Minamino, H. Asanuma, S. Sanada, J. Kim, et al.
Activation of Adenosine A1 Receptor Attenuates Cardiac Hypertrophy and Prevents Heart Failure in Murine Left Ventricular Pressure-Overload Model
Circ. Res., October 17, 2003; 93(8): 759 - 766.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. B. Hansen and J. Schnermann
Vasoconstrictor and vasodilator effects of adenosine in the kidney
Am J Physiol Renal Physiol, October 1, 2003; 285(4): F590 - F599.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
V. Vallon
Tubuloglomerular Feedback and the Control of Glomerular Filtration Rate
Physiology, August 1, 2003; 18(4): 169 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. W. Inscho
Modulation of renal microvascular function by adenosine
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R23 - R25.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Schnermann
The Juxtaglomerular Apparatus: From Anatomical Peculiarity to Physiological Relevance
J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1681 - 1694.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. Mrowka, K. Steinhage, A. Patzak, and P. B. Persson
An evolutionary approach for identifying potential transcription factor binding sites: the renin gene as an example
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1147 - R1150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
F. Schweda, C. Wagner, B. K. Kramer, J. Schnermann, and A. Kurtz
Preserved macula densa-dependent renin secretion in A1 adenosine receptor knockout mice
Am J Physiol Renal Physiol, April 1, 2003; 284(4): F770 - F777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Leipziger
Control of epithelial transport via luminal P2 receptors
Am J Physiol Renal Physiol, March 1, 2003; 284(3): F419 - F432.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Ehmke
Mouse gene targeting in cardiovascular physiology
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R28 - R30.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. Ollerstam and A.E. G Persson
Macula densa neuronal nitric oxide synthase
Cardiovasc Res, November 1, 2002; 56(2): 189 - 196.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Nishiyama and L. G. Navar
ATP mediates tubuloglomerular feedback
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R273 - R275.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Schnermann
Adenosine mediates tubuloglomerular feedback
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R276 - R277.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Nishiyama and L. G. Navar
Response to J. Schnermann: Adenosine mediates tubuloglomerular feedback
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): Ra278 - Ra280.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. A. Janssen and J. F. M. Smits
Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1545 - R1564.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
B. B. Fredholm, A. P. IJzerman, K. A. Jacobson, K.-N. Klotz, and J. Linden
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Pharmacol. Rev., December 1, 2001; 53(4): 527 - 552.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
Tubuloglomerular feedback in adenosine A1 receptor-deficient mice
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1361 - R1361.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2001 by the American Physiological Society.