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Am J Physiol Regul Integr Comp Physiol (September 5, 2002). doi:10.1152/ajpregu.00475.2002
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Articles in PresS, published online ahead of print September 5, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00475.2002
Submitted on August 9, 2002
Accepted on September 3, 2002

Transepithelial Sulfate Transport by Avian Renal Proximal Tubule Epithelium in Primary Culture

Paul L Dudas1 and J. Larry Renfro1*

1 Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA

* To whom correspondence should be addressed. E-mail: jlrenfro{at}uconnvm.uconn.edu.

The mechanisms and control of transepithelial inorganic sulfate (Si) transport by primary cultures of chick renal proximal tubule monolayers in Ussing chambers were determined. The competitive anion, S2O32- (5 mM), reduced both unidirectional reabsorptive and secretory fluxes and net Si reabsorption with no effect on electrophysiological properties. The carbonic anhydrase (CA)inhibitor ethoxzolamide decreased net Si reabsorption ~ 45%. CAII protein and activity were detected in isolated chick proximal tubules by immunoblots and biochemical assay, respectively. Cortisol reduced net Si reabsorption up to about 50% in a concentration dependent manner. Thyroid hormone increased net Si reabsorption 3-fold in 24h, and parathyroid hormone acutely stimulated net Si reabsorption ~ 45%. These data indicate that CA participates in avian proximal tubule active transepithelial Si reabsorption which cortisol directly inhibits and T3 and PTH directly stimulate.




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