| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
2 Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA
* To whom correspondence should be addressed. E-mail: jbd131{at}psu.edu.
CCK-A receptor deficient OLETF rats are hyperphagic and develop obesity and type-2 diabetes. In this strain, taste preference functions have not been investigated. Therefore, a series of short access, two-bottle tests were performed in age-matched pre-diabetic OLETF and non-mutant LETO rats to investigate preference for sucrose (0.03M, 0.1M, 0.3M, 1.0M) presented with a choice of water. To discern orosensory from post-gastric factors that may contribute to this preference, in a separate experiment, rats were allowed to sham feed sucrose in the absence or presence of duodenal sucrose infusion (0.3M, 0.6M, 1.0M). In the two-bottle real-feeding tests, OLETF rats exhibited a greater preference for 0.3M (91.2 ± 1.7 % and 78.5 ± 3.4 % for OLETF and LETO, respectively; P<0.01) and 1.0M (65.3 ± 1.2 % and 57.5 ± 2.7 % for OLETF and LETO, respectively; P<0.05) sucrose compared to LETO rats. Furthermore, OLETF rats sham fed less of the lowest (0.03M; 33.8 ± 4.8 ml and 58.3 ± 7.3 ml for OLETF and LETO, respectively; P<0.05) and more of the highest (1.0M; 109.9 ± 6.5 ml and 81.0 ± 3.9 ml for OLETF and LETO, respectively; P<0.01) concentration of sucrose relative to LETO. Finally, intraduodenal sucrose infusions (0.6M and 1.0M) produced a smaller reduction of 0.3M sham sucrose intake (14.1 ± 8.1 ml vs. 52.5 ± 3.3 ml, and 49.4 ± 8.0 ml vs. 82.4 ± 3.2 ml for 0.6M and 1.0M infusions in OLETF and LETO, respectively; P<0.01 and P<0.05 for 0.6M and 1.0M infusions, respectively). These findings demonstrate that OLETF rats display an increased preference for sucrose, an effect that is at least partially influenced by the orosensory stimulating effect of sucrose. This enhanced responsiveness to oral stimulation, coupled with the deficit in responding to the postingestive feedback of intestinal sucrose may contribute additively to the development of hyperphagia and weight gain in OLETF rats.
This article has been cited by other articles:
|
|
 |
|
  P. Kovacs and A. Hajnal Altered Pontine Taste Processing in a Rat Model of Obesity J Neurophysiol, October 1, 2008; 100(4): 2145 - 2157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Roussin and P. M. Di Lorenzo Oh, How Sweet It Is. Focus on "Altered Pontine Processing in a Rat Model of Obesity" J Neurophysiol, October 1, 2008; 100(4): 1697 - 1698. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hajnal, N. K. Acharya, P. S. Grigson, M. Covasa, and R. C. Twining Obese OLETF rats exhibit increased operant performance for palatable sucrose solutions and differential sensitivity to D2 receptor antagonism Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1846 - R1854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Anderzhanova, M. Covasa, and A. Hajnal Altered basal and stimulated accumbens dopamine release in obese OLETF rats as a function of age and diabetic status Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R603 - R611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. De Jonghe, A. Hajnal, and M. Covasa Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1819 - R1827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. De Jonghe, A. Hajnal, and M. Covasa Decreased gastric mechanodetection, but preserved gastric emptying, in CCK-1 receptor-deficient OLETF rats Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G640 - G649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Blumberg, D. Haba, M. Schroeder, G. P. Smith, and A. Weller Independent ingestion and microstructure of feeding patterns in infant rats lacking CCK-1 receptors Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R208 - R218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hajnal, M. Covasa, and N. T. Bello Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1675 - R1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Physiological regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
