AJP - Regu AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (August 10, 2006). doi:10.1152/ajpregu.00496.2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
292/1/R382    most recent
00496.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Samson, W. K.
Right arrow Articles by White, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Samson, W. K.
Right arrow Articles by White, M. M.
Submitted on July 13, 2006
Accepted on August 9, 2006

The Hypocretin/Orexin Type 1 Receptor in Brain: A Role in Cardiovascular Control and the Neuroendocrine Response to Immobilization Stress

Willis K. Samson1*, Sara L. Bagley1, Alastair V. Ferguson2, and Meghan M. White1

1 Pharmacology and Physiology, St. Louis University School of Medicine, St. Louis, Missouri, United States
2 Physiology, Queen's University, Kingston, Canada

* To whom correspondence should be addressed. E-mail: samsonwk{at}slu.edu.

Hypocretin/Orexin acts pharmacologically in hypothalamus to stimulate stress hormone secretion at least in part by an action in the hypothalamic paraventricular nucleus where orexin receptors have been localized. In addition orexin acts in brain to increase sympathetic tone and therefore mean arterial pressure and heart rate. We provide evidence for the role of endogenously produced hypocretin/orexin in the physiologic response to immobilization stress and identify the receptor subtype responsible for this action of the peptide. Antagonism of the type-1 receptor in brain prevented the ACTH-stimulating effect of centrally administered hypocretin/orexin. Furthermore, pretreatment of animals with the hypocretin/orexin type-1 receptor antagonist blocked the ACTH response to immobilization/restraint stress. The type-1 receptor antagonist did not, however, block the pharmacologic or physiologic releases of prolactin in these two models. Antagonism of the type-1 receptor also blocked the central action of orexin to elevate mean arterial pressures and heart rates in conscious rats. These data suggest receptor sub-type selective responses to hypocretin/orexin and provide further evidence for the importance of endogenously produced peptide in the physiologic control of stress hormone secretion.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Wenzel, N. Grabinski, C. A. Knopp, A. Dendorfer, M. Ramanjaneya, H. S. Randeva, M. Ehrhart-Bornstein, P. Dominiak, and O. Johren
Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2009; 297(5): R1601 - R1609.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. L. C. Yosten and W. K. Samson
Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2009; 297(2): R330 - R336.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. C. da Costa Goncalves, J. Tank, A. Diedrich, A. Hilzendeger, R. Plehm, M. Bader, F. C. Luft, J. Jordan, and V. Gross
Diabetic Hypertensive Leptin Receptor-Deficient db/db Mice Develop Cardioregulatory Autonomic Dysfunction
Hypertension, February 1, 2009; 53(2): 387 - 392.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. C. da Costa-Goncalves, J. Tank, R. Plehm, A. Diedrich, M. Todiras, M. Gollasch, A. Heuser, M. Wellner, M. Bader, J. Jordan, et al.
Role of the Multidomain Protein Spinophilin in Blood Pressure and Cardiac Function Regulation
Hypertension, October 1, 2008; 52(4): 702 - 707.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Rao, M. Lu, F. Ge, D. J. Marsh, S. Qian, A. H. Wang, M. R. Picciotto, and X.-B. Gao
Regulation of Synaptic Efficacy in Hypocretin/Orexin-Containing Neurons by Melanin Concentrating Hormone in the Lateral Hypothalamus
J. Neurosci., September 10, 2008; 28(37): 9101 - 9110.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.