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Am J Physiol Regul Integr Comp Physiol (September 30, 2004). doi:10.1152/ajpregu.00499.2004
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Submitted on July 26, 2004
Accepted on September 27, 2004

Restraint stress delays solid gastric emptying via a central corticotropin-releasing factor and peripheral sympathetic neuron in rats

Yukiomi Nakade1, Daisuke Tsuchida1, Hiroyuki Fukuda1, Masahiro Iwa1, Theodore N Pappas1, and Toku Takahashi1*

1 Department of Surgery, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA

* To whom correspondence should be addressed. E-mail: ttakahas{at}duke.edu.

Central corticotropin-releasing factor (CRF) delays gastric emptying through the autonomic nervous system. CRF plays an important role in mediating delayed gastric emptying induced by stress. However, it is not clear whether a sympathetic or parasympathetic pathway is involved in the mechanism of central CRF-induced inhibition of solid gastric emptying. The purpose of this study was to investigate whether (a): CRF inhibits solid gastric emptying via a peripheral sympathetic pathway and (b): stress-induced inhibition of solid gastric emptying is mediated via a central CRF and peripheral sympathetic pathways. Using male Sprague-Dawley rats, CRF was injected intracisternally with or without various adrenergic blocking agents. To investigate whether central CRF induced-inhibition of solid gastric emptying is mediated via a peripheral sympathetic pathway, rats underwent celiac ganglionectomy one week prior to the gastric emptying study. Ninety minutes after solid meal ingestion, gastric emptying was calculated. To investigate the role of endogenous CRF in stress-induced delayed gastric emptying, a CRF type2 receptor antagonist, astressin2-B, was intracisternally (IC) administered. Rats were subjected to a restraint stress immediately after the feeding. IC injection of CRF (0.1-1.0 µg) dose-dependently inhibited solid gastric emptying. The inhibitory effect of CRF on solid gastric emptying was significantly blocked by guanethidine, propranolol and celiac ganglionectomy, but not by phentolamine. Restraint stress significantly delayed solid gastric emptying, which was improved by astressin2-B, guanethidine and celiac ganglionectomy. Our research suggests that restraint stress inhibits solid gastric emptying via a central CRF type2 receptor and peripheral sympathetic neural pathway in rats.




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