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Am J Physiol Regul Integr Comp Physiol (February 15, 2007). doi:10.1152/ajpregu.00503.2006
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Submitted on July 17, 2006
Accepted on February 12, 2007

Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining

Kirsten A. Burgomaster1, Naomi M. Cermak1, Stuart M. Phillips1, Carley R. Benton2, Arend Bonen3, and Martin J. Gibala1*

1 Department of Kinesiology, McMaster University, Hamilton, Canada
2 Department of Kinesiology, University of Waterloo, Waterloo, Canada
3 Department of Human Biology, University of Guelph, Guelph, Canada

* To whom correspondence should be addressed. E-mail: gibalam{at}mcmaster.ca.

Skeletal muscle primarily relies on carbohydrate (CHO) for energy provision during high-intensity exercise. We hypothesized that sprint interval training (SIT), or repeated sessions of high-intensity exercise, would induce rapid changes in transport proteins associated with CHO metabolism, whereas changes in skeletal muscle fatty acid transporters would occur more slowly. Eight active men (22±1 y; peak oxygen uptake = 50±2 ml/kg/min) performed 4-6 x 30-s all out cycling efforts with 4 min recovery, 3 d/wk for 6 wk. Needle muscle biopsy samples (v. lateralis) were obtained before training (Pre), after 1 and 6 wk of SIT and after 1 and 6 wk of detraining. Muscle oxidative capacity, as reflected by the protein content of cytochrome c oxidase subunit 4 (COX4), increased by ~35% after 1 wk of SIT and remained higher compared to Pre even after 6 wk of detraining (P<0.05). Muscle GLUT4 content increased after 1 wk of SIT and remained ?20% higher compared to baseline during detraining (P<0.05). The monocarboxyate tranporter (MCT) 4 was higher after 1 and 6 wk of SIT compared to Pre, whereas MCT1 increased after 6 wk of training and remained higher after 1 wk of detraining (P<0.05). There was no effect of training or detraining on the muscle content of fatty acid translocase (FAT/CD36) or plasma membrane associated fatty acid binding protein (FABPpm) (P>0.05). We conclude that short-term SIT induces rapid increases in skeletal muscle oxidative capacity but has divergent effects on proteins associated with glucose, lactate and fatty acid transport.




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