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1 Laboratory of Biochemistry, Bicetre Hospital, Le Kremlin-Bicetre, France
2 Claude Bernard Association, Broussais Hospital, Paris, France
3 Claude Bernard Association, Broussais Hospital, Paris, France; Laboratory of Biochemistry, Charles Foix Hospital, Ivry, France; Laboratory of Applied Biochemistry, Faculty of Pharmaceutical and Biological Sciences, Chatenay-Malabry, France
* To whom correspondence should be addressed. E-mail: patrick.bruneval{at}hop.egp.ap-hop-paris.fr.
Chronic renal failure often induces left ventricular hypertrophy. We assessed whether the heart is affected in Zucker obese rat, a model of chronic renal failure associated with obesity, glucose intolerance, and insulin resistance without hypertension or hyperglycemia. After systemic blood pressure measurement, the heart, the aorta, and the kidneys were removed from anesthetized 9 and 13 month-old Zucker obese and lean control male rats (n = 33, n = 24, n = 25, and n = 21, respectively). Determination of left ventricular geometry, quantification of myocardium collagen density and measurement of heart antioxidant enzyme activity were made, as well as aorta and kidney parameters. Mean blood pressure remained at a normal range whatever the age and group considered. Whereas kidney structure and function were severely impaired, no sign of myocardial infarction or inflammatory process was noticed. A moderate left ventricular hypertrophy was observed in 13 months-old obese rats. While heart malondialdehyde was stable with age and among groups, antioxidant enzyme activity was higher in obese rats. In conclusion, in absence of hypertensive or hyperglycemic disorders, the heart seems to display a sufficient line of defense against oxidative stress during the development of cardiac hypertrophy.
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