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Am J Physiol Regul Integr Comp Physiol (August 1, 2002). doi:10.1152/ajpregu.00525.2001
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Articles in PresS, published online ahead of print August 1, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00525.2001
Submitted on August 31, 2001
Accepted on July 22, 2002

Effects of rearing temperature on sympathoadrenal activity in young adult rats

James B Young1*, Jeffrey Weiss1, and Nadine Boufath1

1 Department of Medicine, Northwestern University School of Medicine, Chicago, IL, USA

* To whom correspondence should be addressed. E-mail: jbyoung{at}northwestern.edu.

Animals reared at 18°C exhibit enhanced innervation of brown adipose tissue (BAT) and greater cold tolerance as adults, yet gain more weight when fed an enriched diet compared to rats reared at 30°C. To explore this paradox, sympathoadrenal activity was examined using techniques of [3H]norepinephrine ([ 3H]NE) turnover and urinary catecholamine excretion in male and female rats reared until 2 months of age at 18°C or 30°C. Gene expression in BAT was also analyzed for several sympathetically-related proteins. Although [3H]NE turnover in heart did not differ between groups, [3H]NE turnover in BAT was consistently elevated in the 18°C-reared animals, even 2 months after removal from the cool environment. Gene expression for uncoupling proteins 1 and 3, GLUT4, leptin and the {alpha}1A-adrenergic receptor was more abundant in BAT and the increase in epinephrine excretion with fasting suppressed in 18°C-reared animals. These studies demonstrate that obesity consequent to exposure to 18°C in early life occurs despite tonic elevation of sympathetic input to BAT. Diminished adrenal Epi responsiveness to fasting may play a contributory role.




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