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Am J Physiol Regul Integr Comp Physiol (November 21, 2002). doi:10.1152/ajpregu.00525.2002
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Articles in PresS, published online ahead of print November 21, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00525.2002
Submitted on August 29, 2002
Accepted on November 18, 2002

Brown fat and non-shivering thermogenesis in the gray mouse lemur (Microcebus murinus)

Fabien Genin1*, Maryse Nibbelink2, Matthieu Galand1, Martine Perret1, and Louis Ambid2

1 Laboratoire d'Ecologie, CNRS-UMR8571, Brunoy, 91800, France
2 Laboratoire de Neurobiologie, Plasticite Tissulaire et Metabolisme Energetique, CNRS-UMR5018, Toulouse, 31403, France

* To whom correspondence should be addressed. E-mail: fabien.genin{at}free.fr.

The gray mouse lemur Microcebus murinus is a rare example of a primate exhibiting daily torpor. In captive animals, we examined the metabolic rate during arousal from torpor and showed that this process involved non-shivering thermogenesis (NST). Under thermoneutrality (28°C), warming up from daily torpor (body temperature < 33°C) involved a rapid (< 5 min) increase of O2 consumption that was proportional to the depth of torpor (n = 8). The injection of a {beta}-adrenergic agonist (isoproterenol) known to elicit NST induced a dose-dependent increase in metabolic rate (n = 8). Moreover, maximum thermogenesis was increased by cold exposure. For the first time in this species, anatomical and histological examination using an antibody against uncoupling protein UCP, specifically demonstrated the presence of brown fat. Using Western blotting with the same antibody, we showed a likely increase in UCP expression after cold exposure, suggesting that NST is also used to survive low ambient temperatures in this tropical species.




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