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1 Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA
2 Department of Physics, Danish Technical University, Lyngby, Denmark
3 Department of Physics, Saratov State University, Saratov, Russia
4 Department of Physiology and Biophysics, University of South Florida, Tampa, FL, USA
5 Department of Medical Physiology, University of Copenhagen, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: marsh{at}ash.biomed.brown.edu.
With a model of renal blood flow regulation we examined consequences of tubuloglomerular feedback (TGF) coupling tothe myogenic mechanism via voltage gated Ca channels. The model reproduces the characteristic oscillations of the twomechanisms, and predicts frequency and amplitude modulationof the myogenic oscillation by TGF. Analysis by wavelet transforms of single nephron blood flow confirms that both amplitude and frequency of the myogenic oscilltion are modulated by TGF. We developed a double wavelet transform technique to estimate modulation frequency. Median value of the ratio of modulation frequency to TGF frequency in measurements from 10 rats was 0.95 for amplitude modulaion and 0.97 for frequency modulation, a result consistent with TGFas the modulating signal. The simulation predicted that the modulation was regular, while the experimental data showed much greater variability from one TGF cycle to the next. We used a blood pressure signal recorded by telemetry from a conscious rat as the input to the model. Blood pressure fluctuations induced variability in the modulationrecords similar to those found in the nephron blood flow results. Frequency and amplitude modulation can provide robust communication between TGF and the myogenic mechanism.
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