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Am J Physiol Regul Integr Comp Physiol (June 3, 2004). doi:10.1152/ajpregu.00542.2003
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Submitted on September 22, 2003
Accepted on May 14, 2004

ABSENCE OF THE CHOLECYSTOKININ-A RECEPTOR DETERIORATES HOMEOSTASIS OF BODY TEMPERATURE IN RESPONSE TO CHANGES IN AMBIENT TEMPERATURE

Shigeki Nomoto1, Minoru Ohta2, Setsuko Kanai2, Yuki Yoshida2, Soichi Takiguchi3, Akihiro Funakoshi4, and Kyoko Miyasaka2*

1 Motor and Autonomic Nervous System Integration, Tokyo Metropolitan Institute of Gerontology, Tokyo, Tokyo, Japan
2 Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Tokyo, Japan
3 Research Institute, National Kyushu Cancer Center, Fukuoka, Fukuoka, Japan
4 Department of Gastroenterology, National Kyushu Cancer Center, Fukuoka, Fukuoka, Japan

* To whom correspondence should be addressed. E-mail: miyasaka{at}tmig.or.jp.

The circadian rhythm of the body core temperature (Tc) and the effects of changes in ambient temperatures on the the homeostasis of Tc in Otsuka Long Evans Tokushima Fatty (OLETF) rats, which are naturally occurring cholecystokinin (CCK)-A receptor (R) gene knockout rats, were examined. In addition the peripheral responses to warming or cooling of the preoptic and anterior hypothalamic region (PO/AH) were determined. The circadian rhythm of Tc in OLETF rats was similar to that in Long-Evans Tokushima (LETO) rats; this rhythm was characterized by a higher Tc during the dark period and a lower Tc during the light period. When the ambient temperature was changed within the limits of 0°C to 30°C, the changes in Tc of LETO rats were associated with the changes in ambient temperature, whereas those in OLETF rats were dissociated from the temperature changes. The OLETF rats showed a large hysteresis. The peripheral responses to warming or cooling of PO/AH, including shivering of the neck muscle and changes in skin temperature of the tail and footpad, were similar in OLETF and LETO rats. To confirm the role of CCK-AR in the regulation of body temperature, the values of Tc in the CCK-AR gene knockout (-/-) mice were compared with those in CCK-BR(-/-), AR(-/-)BR(-/-) and in wild-type mice. In the mice, the circadian rhythms of Tc were the same, regardless of the genotype. Mice without CCK-AR showed larger hysteresis than mice with CCK-AR. From these results, we conclude that the lack of CCK-AR causes homeostasis of Tc in rats and mice to deteriorate.




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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Z. Szelenyi
Neuronal CCK and thermoregulation: two receptors with different functions
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R109 - R111.
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