AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (January 23, 2003). doi:10.1152/ajpregu.00544.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/6/R1494    most recent
00544.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Simon, S. A
Right arrow Articles by Erickson, R. P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Simon, S. A
Right arrow Articles by Erickson, R. P
Submitted on September 6, 2002
Accepted on January 23, 2003

Neuropeptides modulate rat chorda tympani responses

Sidney A Simon1*, Lieju Liu1, and Robert P Erickson1

1 Neurobiology, Duke University, Durham, NC, USA

* To whom correspondence should be addressed. E-mail: sas{at}neuro.duke.edu.

The neuropeptide leptin has been shown to selectively modulate rat chorda tympani (CT) responses to sweet tastants. To explore whether other neuropeptides can modulate such responses, rat whole nerve CT responses to NaCl, HCl, quinine HCl and sucrose were measured while administering cholecystokinin(CCK-8), SubstanceP4-11, or calcitonin-gene-related-peptide (CGRP). To avoid possible confounding effects on CT responses that take long times to develop, such as those that arise from intraperitoneal injections, we investigated the effects of the above peptides injected into the ipsilateral lingual artery (LA) on CT nerve responses during the initial seconds after a tastant was placed on the tongue. We found that CT responses to NaCl and HCl were increased by CCK-8 and decreased by CGRP. SP4-11 had no noticeable effect. Peptide-induced CT responses to quinine HCl or sucrose were too small to accurately detect. These data suggest that at short latencies, following local infusion via the LA, neuropeptides can alter CT responses in a peptide-specific manner.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
P. Kovacs and A. Hajnal
Altered Pontine Taste Processing in a Rat Model of Obesity
J Neurophysiol, October 1, 2008; 100(4): 2145 - 2157.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
V. Lyall, G. L. Heck, T.-H. T. Phan, S. Mummalaneni, S. A. Malik, A. K. Vinnikova, and J. A. DeSimone
Ethanol Modulates the VR-1 Variant Amiloride-insensitive Salt Taste Receptor. I. Effect on TRC Volume and Na+ Flux
J. Gen. Physiol., May 31, 2005; 125(6): 569 - 585.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
V. Lyall, G. L. Heck, T.-H. T. Phan, S. Mummalaneni, S. A. Malik, A. K. Vinnikova, and J. A. DeSimone
Ethanol Modulates the VR-1 Variant Amiloride-insensitive Salt Taste Receptor. II. Effect on Chorda Tympani Salt Responses
J. Gen. Physiol., May 31, 2005; 125(6): 587 - 600.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.