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Am J Physiol Regul Integr Comp Physiol (January 24, 2002). doi:10.1152/ajpregu.00548.2001
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Articles in PresS, published online ahead of print January 24, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00548.2001
Submitted on September 6, 2001
Accepted on December 18, 2001

Early osmoregulatory stimulation of thirst and neurohypophyseal hormone secretion after gastric NaCl loads in rats

Edward M Stricker1*, John B Callahan1, Wan Huang1, and Alan F Sved1

1 Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA

* To whom correspondence should be addressed. E-mail: sved{at}bns.pitt.edu.

Cerebral osmoreceptors mediate thirst and neurohypophyseal secretion stimulated by increases in the effective osmolality of plasma (Posmol). The present experiments determined whether an intragastric load of hypertonic saline (i.g. HS; 0.5 M NaCl, 4 ml) would potentiate these responses before induced increases in Posmol in the general circulation could be detected by cerebral osmoreceptors. Adult rats deprived of water overnight and then given i.g. HS consumed much more water in 15-30 min than rats given either pretreatment alone, even though systemic Posmol had not yet increased significantly due to the gastric load. In other rats pretreated with an i.v. infusion of 1 M NaCl (2 ml/h for 2 h), plasma levels of vasopressin and oxytocin were considerably elevated 15 and 25 min after i.g. HS treatment whereas systemic Posmol was not further increased. These and other findings are consistent with previous reports that hepatic portal osmoreceptors (or Na+-receptors) stimulate thirst and neurohypophyseal hormone secretion in euhydrated rats given gastric NaCl loads, and indicate that these effects are potentiated when animals are dehydrated.




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