| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
2 Public Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA
3 Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
* To whom correspondence should be addressed. E-mail: sdevaskar{at}mednet.ucla.edu.
We investigated the effect of repetitive postnatal (2-7d) intracerebroventricular (ICV) administration of neuropeptide Y (NPY) on food intake and body weight gain in the 3 to 120d old Sprague-Dawley rats. NPY caused a 32% transient increase in body weight gain with elevated circulating insulin concentrations within 24 hr. This early intervention led to the persistence of hyperinsulinemia and relative hyperleptinemia with euglycemia in the 120d female alone. This perturbation was associated with 50% suppression in adult female hypothalamic NPY concentrations and a 50-85% decline in NPY immunoreactivity in the paraventricular and arcuate nuclei. This change was paralleled by a ~20% decline in food intake and body weight gain at 60 and 120d. However, when exogenous NPY was stereotaxically reinjected into the paraventricular nucleus of the ~120d adult females who were pretreated with NPY postnatally, an increase in food intake and body weight gain was noted attesting to no disruption in the NPY end-organ responsivity. We conclude that postnatal ICV NPY has long lasting effects that predetermine the resultant adult phenotype in a sex-specific manner.
This article has been cited by other articles:
|
|
 |
|
  W. A. Cupples Physiological regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443. [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Mcmillen and J. S. Robinson Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming Physiol Rev, April 1, 2005; 85(2): 571 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Varma, J. He, B.-C. Shin, L. A. Weissfeld, and S. U. Devaskar Postnatal intracerebroventricular exposure to leptin causes an altered adult female phenotype Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1132 - E1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. He, A. Varma, L. A. Weissfeld, and S. U. Devaskar Postnatal glucocorticoid exposure alters the adult phenotype Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R198 - R208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-D. Wagner and H. Scholz The long-lasting impact of postnatal neuropeptide Y Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1382 - R1383. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
