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Am J Physiol Regul Integr Comp Physiol (December 4, 2003). doi:10.1152/ajpregu.00559.2003
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Submitted on September 26, 2003
Accepted on November 27, 2003

Effect of high NaCl or high KCl diet on hepatic Na+- and K+-receptor sensitivity and NKCC1 expression in rats

You Tsuchiya1, Shigeru Nakashima2, Yoshiko Banno2, Yuichi Suzuki3, and Hironobu Morita4*

1 Department of Physiology, Gifu University School of Medicine, Gifu, Japan; Department of Food and Nutritional Sciences, Shizuoka Prefectural University, Shizuoka, Japan
2 Department of Biochemistry, Gifu University School of Medicine, Gifu, Japan
3 Department of Food and Nutritional Sciences, Shizuoka Prefectural University, Shizuoka, Japan
4 Department of Physiology, Gifu University School of Medicine, Gifu, Japan

* To whom correspondence should be addressed. E-mail: morita{at}cc.gifu-u.ac.jp.

We previously reported that the bumetanide-sensitive Na+-K+-2Cl- cotransporter (NKCC1) is involved in the hepatic Na+ and K+ sensor mechanism. In the present study, we examined the effects of a high NaCl or high KCl diet on hepatic Na+ and K+ receptor sensitivity and NKCC1 expression in the liver of Sprague-Dawley rats. RT-PCR and Western blots were used to measure NKCC1 mRNA and protein expression, respectively. Infusion of hypertonic NaCl or isotonic KCl + NaCl solutions into the portal vein increased hepatic afferent nerve activity (HANA) in a Na+ or K+ dose-dependent manner. After 4 weeks on a high NaCl or high KCl diet, HANA responses were attenuated compared to animals fed a normal diet, and NKCC1 expression was reduced. These results show that a high NaCl or high KCl diet decreases NKCC1 expression in the liver and it might cause a reduction in hepatic Na+- and K+-receptor sensitivity.




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