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Am J Physiol Regul Integr Comp Physiol (December 2, 2004). doi:10.1152/ajpregu.00570.2004
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Submitted on August 20, 2004
Accepted on November 29, 2004

Subfornical organ disconnection alters Fos expression in the lamina terminalis, supraoptic nucleus and area postrema after intragastric hypertonic NaCl

Julia A Freece1, Julie E Van Bebber1, Dannielle K Zierath1, and Douglas A Fitts1*

1 Department ot Psychology, University of Washington, Seattle, WA, USA

* To whom correspondence should be addressed. E-mail: dfitts{at}u.washington.edu.

The lamina terminalis was severed by a horizontal knife cut through the anterior commissure in order to determine the effect of a disconnection of the subfornical organ (SFO) on drinking and Fos-like immunoreactivity (Fos-ir) in the rat brain in response to an intragastric load of hypertonic saline (5 ml/kg of 1.5 M NaCl by gavage). After an initial load, knife-cut rats drank significantly less water than sham-cut rats, thus confirming a role for the SFO in osmotic drinking. After a second load at least a week later, the rats were not allowed to drink after the gavage and were perfused for analysis of Fos-ir at 90 min. Compared to sham-cut rats, the knife-cut rats displayed significantly elevated Fos-ir in the main body of the SFO, in the dorsal cap of the organum vasculosum laminae terminalis, and in the ventral median preoptic nucleus after the hypertonic load. The knife cut significantly decreased Fos-ir in the supraoptic nucleus. Fos-ir was expressed mainly in the mid-coronal and caudal parts of the area postrema of sham-cut rats, and this expression was greatly reduced in knife-cut rats. These findings strengthen the case for the presence of independently functioning osmoreceptors within the SFO and suggest that the structures of the lamina terminalis provide mutual inhibition during hypernatremia. They also demonstrate that the Fos-ir in the area postrema after intragastric osmotic loading is heavily dependent on the intact connectivity of the SFO.




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