AJP - Regu Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (December 2, 2004). doi:10.1152/ajpregu.00570.2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
288/4/R947    most recent
00570.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Freece, J. A
Right arrow Articles by Fitts, D. A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Freece, J. A
Right arrow Articles by Fitts, D. A
Submitted on August 20, 2004
Accepted on November 29, 2004

Subfornical organ disconnection alters Fos expression in the lamina terminalis, supraoptic nucleus and area postrema after intragastric hypertonic NaCl

Julia A Freece1, Julie E Van Bebber1, Dannielle K Zierath1, and Douglas A Fitts1*

1 Department ot Psychology, University of Washington, Seattle, WA, USA

* To whom correspondence should be addressed. E-mail: dfitts{at}u.washington.edu.

The lamina terminalis was severed by a horizontal knife cut through the anterior commissure in order to determine the effect of a disconnection of the subfornical organ (SFO) on drinking and Fos-like immunoreactivity (Fos-ir) in the rat brain in response to an intragastric load of hypertonic saline (5 ml/kg of 1.5 M NaCl by gavage). After an initial load, knife-cut rats drank significantly less water than sham-cut rats, thus confirming a role for the SFO in osmotic drinking. After a second load at least a week later, the rats were not allowed to drink after the gavage and were perfused for analysis of Fos-ir at 90 min. Compared to sham-cut rats, the knife-cut rats displayed significantly elevated Fos-ir in the main body of the SFO, in the dorsal cap of the organum vasculosum laminae terminalis, and in the ventral median preoptic nucleus after the hypertonic load. The knife cut significantly decreased Fos-ir in the supraoptic nucleus. Fos-ir was expressed mainly in the mid-coronal and caudal parts of the area postrema of sham-cut rats, and this expression was greatly reduced in knife-cut rats. These findings strengthen the case for the presence of independently functioning osmoreceptors within the SFO and suggest that the structures of the lamina terminalis provide mutual inhibition during hypernatremia. They also demonstrate that the Fos-ir in the area postrema after intragastric osmotic loading is heavily dependent on the intact connectivity of the SFO.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Ho, D. K. Zierath, A. V. Savos, D. J. Femiano, J. E. Bassett, M. J. McKinley, and D. A. Fitts
Differential effects of intravenous hyperosmotic solutes on drinking latency and c-Fos expression in the circumventricular organs and hypothalamus of the rat
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1690 - R1698.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. B. Nahey and J. P. Collister
ANG II-induced hypertension and the role of the area postrema during normal and increased dietary salt
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H694 - H700.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. E. Haley and F. W. Flynn
Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1242 - R1250.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.