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Articles in PresS, published online ahead of print March 14, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00583.2001
Submitted on September 24, 2001
Accepted on February 14, 2002
1 Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
* To whom correspondence should be addressed. E-mail: Santos{at}icb.ufmg.br.
In this study we evaluated by telemetry the effects of angiotensin (Ang) II and Ang-(1-7) infusion on the circadian rhythms of blood pressure (BP) and heart rate (HR) and on the cardiovascular adjustment resulting from restraint stress in rats. Ang II or Ang-(1-7) or vehicle were infused subcutaneously for 7 days. Restraint stress was carried out before, during and after infusion, at 7 days intervals. In parallel with an increase in MAP, Ang II infusion produced an inversion of MAP circadian rhythm with a significant MAP acrophase inversion. It also produced bradycardia during the first three days of infusion. Thereafter, HR progressively increased reaching values similar or above to those of the control period, at the end of the infusion period. HR circadian variation was not changed by Ang II infusion. Strikingly, Ang II significantly attenuated the increase in MAP induced by restraint stress, without altering the HR response. Ang-(1-7) infusion produced a slight but significant decrease in MAP restricted to the day time period. No significant changes in the MAP acrophase were observed. In addition, Ang-(1-7) infusion produced a small but significant sustained bradycardia. Ang (1-7) did not change cardiovascular responses to restraint stress. These data indicate that Ang II can influence the activity of brain areas involved in the determination of stress-induced or circadian-dependent variations of blood pressure, without changing HR fluctuations. A significant modulatory influence of Ang-(1-7)on basal MAP and HR is also suggested.
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