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Am J Physiol Regul Integr Comp Physiol (January 17, 2002). doi:10.1152/ajpregu.00584.2001
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Articles in PresS, published online ahead of print January 17, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00584.2001
Submitted on September 24, 2001
Accepted on December 11, 2001

Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster

Laura Kean1, William Cazenave2, Laurence Costes2, Kate E Broderick1, Shirley Graham1, Valerie P Pollock1, Shireen A Davies1, Jan A Veenstra2, and Julian A Dow1*

1 Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
2 Laboratoire de Neuroendocrinologie des Insectes, Universite de Bordeaux I, Bordeaux, France

* To whom correspondence should be addressed. E-mail: j.a.t.dow{at}bio.gla.ac.uk.

A Drosophila gene (capability, capa), at 99D on chromosome 3R, potentially encodes three neuropeptides, GANMGLYAFPRV-amide (capa-1), ASGLVAFPRV-amide (capa-2), together with TGPSASSGLWGPRLamide (capa-3). Capa-1 and capa-2 are related to the lepidopteran hormone cardioacceleratory peptide 2b (CAP2b), while capa-3 is a novel member of the pheromone biosynthesis activating neuropeptide (PBAN) / diapause hormone / pyrokinin family. By immunocytochemistry, we identified four pairs of neuroendocrine cells likely to release the capa peptides into the haemolymph, one pair in the suboesophageal ganglion and the other three in the abdominal neuromeres. In the Malpighian (renal) tubule, both capa-1 and capa-2 increase fluid secretion rates, stimulate nitric oxide production, and elevate intracellular calcium and cGMP in principal cells. Capa-stimulated fluid secretion, though not [Ca2+]i rise, is inhibited by the guanylate cyclase inhibitor, methylene blue. The actions of capa-1 and capa-2 are not synergistic, implying that they both act on the same pathways in tubules. The capa gene is thus the first to be shown to encode neuropeptides that act on renal fluid production through NO.




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