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Articles in PresS, published online ahead of print January 17, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00597.2001
Submitted on October 1, 2001
Accepted on January 9, 2002
1 Department of Research Service, Veterans Affairs Medical Center, Omaha, NE, USA; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, USA
2 Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, USA
* To whom correspondence should be addressed. E-mail: rogerr{at}creighton.edu.
We previously demonstrated that amylin inhibits food intake and gastric emptying in rats with ED50s of 8 and 3 pmol.kg-1.min-1 and maximal inhibitions of 78 and 60%, respectively. In this study of identical design, rats received IV infusions of salmon calcitonin (sCT), rat calcitonin (rCT), rat calcitonin gene-related peptide (rCGRP), and rat adrenomedullin (rADM) either for 3 h at dark onset and food intake was measured for 17 h, or for 15 min and gastric emptying of saline was measured during the final 5 min. sCT, rCGRP, and rADM inhibited food intake with estimated ED50s of 0.5, 26, and 35 pmol.kg-1.min-1 and maximal inhibitions of 88, 90, and 49%, respectively. rCT was not effective at doses up to 100 pmol.kg-1.min-1. sCT, rCGRP, rADM, and rCT inhibited gastric emptying with ED50s of 1, 130, 160, and 730 pmol.kg-1.min-1 and maximal inhibitions of 60, 66, 60, and 33%, respectively. These results suggest that amylin and sCT may act by a common mechanism to decrease food intake, which includes the inhibition of gastric emptying.
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