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Am J Physiol Regul Integr Comp Physiol (February 3, 2005). doi:10.1152/ajpregu.00602.2004
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Submitted on September 3, 2004
Accepted on February 1, 2005

Long-Evans and Sprague-Dawley rats exhibit divergent responses to refeeding after caloric restriction

S. A Evans1, M. M Messina1, W. D Knight1, A. D Parsons1, and J. Michael Overton1*

1 Department of Nutrition, Food, and Exercise Sciences and, the Program in Neuroscience, Florida State University, Tallahassee, Florida, USA

* To whom correspondence should be addressed. E-mail: moverton{at}mailer.fsu.edu.

Mature male Sprague-Dawley (SD) and Long Evans (LE) rats were instrumented with telemetry transmitters for measurement of heart rate (HR) and housed in room calorimeters for assessment of food intake and oxygen consumption (VO2) at standard lab temperatures (23°C) to examine physiological responses to caloric restriction (CR; 60% of baseline ad lib calories for 2 wks) and refeeding. Ad lib controls had stable food intake (84-88 kcal/d) and gained weight at the rates of 3-4 g/d. Groups from both strains assigned to CR exhibited similar patterns of weight loss and reductions in VO2 and HR. Upon refeeding, SD rats exhibited a mild, transient hyperphagic response (1 day) accompanied by sustained suppression of VO2 and HR that remained evident 8 days after refeeding. In contrast, LE rats exhibited sustained daily hyperphagia that persisted 8 days after refeeding and was accompanied by a complete restoration of HR and VO2. The lower HR and VO2 observed during refeeding in SD rats were not due to reduced locomotor activity. The results reveal a strain-dependent divergent response to recovery from CR. We conclude that during recovery from CR, homeostatic stimulation of appetite or suppression of energy expenditure may occur selectively to restore body weight.




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