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Am J Physiol Regul Integr Comp Physiol (March 25, 2004). doi:10.1152/ajpregu.00607.2003
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Submitted on October 17, 2003
Accepted on March 12, 2004

Expression of Neuropeptide Y1 AND Y5 Receptors in the Hypothalamic Paraventricular Nucleus of Aged Fischer 344 rats

Jessica D Coppola1, Barbara A Horwitz2, Jock Hamilton2, and Roger B McDonald1*

1 Department of Nutrition, University of California, Davis, CA, USA
2 Section of Neurobiology, Physiology, and Behavior, Division of Biological Sciences, University of California, Davis, CA, USA

* To whom correspondence should be addressed. E-mail: rbmcdonald{at}ucdavis.edu.

Many mammals, nearing the end of life, spontaneously decrease their food intake and body weight, a stage we refer to as senescence. The spontaneous decrease in food intake and body weight is associated with attenuated responses to intracerebral ventricular injections of NPY compared to old presenescent or to young adult rats. In the present study, we tested the hypothesis that this blunted responsiveness involves the number and expression of PVN Y1 and/or Y5 NPY receptors, both of which are thought to mediate NPY-induced food intake. We found no significant difference in mRNA levels, via qPCR, for Y1 and Y5 receptors in the PVN of senescent vs. presenescent rats. In contrast, immunohistochemistry indicated that the number of PVN neurons staining for Y1 receptor protein was greater in presenescent compared to senescent rats. We conclude that the decreased expression and number of Y1 or Y5 receptors in the PVN cannot explain the attenuated responsiveness of the senescent rats to exogenous NPY.




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