AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (December 21, 2001). doi:10.1152/ajpregu.00610.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/4/R1096    most recent
00610.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Slomowitz, L. A
Right arrow Articles by Thomson, S. C
Right arrow Search for Related Content
PubMed
Right arrow Articles by Slomowitz, L. A
Right arrow Articles by Thomson, S. C

Articles in PresS, published online ahead of print December 21, 2001
Am J Physiol Regu Physiol, 10.1152/ajpregu.00610.2001
Submitted on October 10, 2001
Accepted on December 7, 2001

Glomerulotubular balance, dietary protein, and the renal response to glycine in diabetic rats

Larry A Slomowitz1, Aihua Deng1, John S Hammes1, Francis B Gabbai2, and Scott C Thomson2*

1 Medicine, University of California, San Diego, CA, none
2 Medicine, University of California, San Diego, CA, none; Medicine, Veterans Affairs Medical Center, San Diego, CA, none

* To whom correspondence should be addressed. E-mail: sthomson{at}popmail.ucsd.edu.

GFR normally increases during glycine infusion, which is a test of "renal reserve." Renal reserve is absent in diabetes mellitus. GFR increases after protein feeding due to increased tubular reabsorption which reduces the signal for tubuloglomerular feedback (TGF). Dietary protein restriction normalizes some aspects of glomerular function in diabetes. Renal micropuncture was performed in rats with 4-5 weeks of streptozotocin diabetes to determine whether renal reserve is lost due to altered tubular function and activation of TGF, whether ten days of dietary protein restriction could restore renal reserve and whether this results from effects of glycine on the tubule. TGF activation was determined by locating single nephron GFR (SNGFRd) along the TGF curve. The TGF signal was determined from the ionic content of the early distal tubule. In nondiabetics, SNGFRd increased during glycine due to primary vasodilation augmented by increased tubular reabsorption which stabilized the TGF signal. In diabetics, glycine reduced reabsorption, thereby activating TGF which was largely responsible for the lack of renal reserve. In protein restricted diabetics, the tubular response to glycine remained abnormal, but renal reserve was restored by a vascular mechanism. Glycine affects GFR directly and via the tubule. In diabetes reduced tubular reabsorption dominates. In low protein diabetes, the vascular effect is enhanced and overrides the effect of reduced tubular reabsorption.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. A. Slomowitz, F. B. Gabbai, S. J. Khang, J. Satriano, S. Thareau, A. Deng, S. C. Thomson, R. C. Blantz, and K. A. Munger
Protein intake regulates the vasodilatory function of the kidney and NMDA receptor expression
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1184 - R1189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. C. Thomson, A. Deng, N. Komine, J. S. Hammes, R. C. Blantz, and F. B. Gabbai
Early diabetes as a model for testing the regulation of juxtaglomerular NOS I
Am J Physiol Renal Physiol, October 1, 2004; 287(4): F732 - F738.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. C. Thomson, V. Vallon, and R. C. Blantz
Kidney function in early diabetes: the tubular hypothesis of glomerular filtration
Am J Physiol Renal Physiol, January 1, 2004; 286(1): F8 - F15.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2001 by the American Physiological Society.