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Am J Physiol Regul Integr Comp Physiol (September 26, 2007). doi:10.1152/ajpregu.00615.2007 Free Article
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Submitted on August 24, 2007
Accepted on September 20, 2007

Leukocytes of Exceptionally Old Persons Display Ultra-short Telomeres

Masayuki Kimura1*, M Barbieri2, J P Gardner1, Joan Skurnick1, Xiaojian Cao1, N van Riel3, M R Rizzo2, Giuseppe Paolisso2, and Abraham Aviv1

1 The Center of Human Development and Aging, University of Medicine & Dentistry of New Jersey, Newark, New Jersey, United States
2 Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
3 Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

* To whom correspondence should be addressed. E-mail: kimurama{at}umdnj.edu.

With a view to understanding the association between leukocyte telomere length and the human lifespan, we performed genome-wide telomere length analyses by the terminal restriction fragment length (TRFL) and single molecule telomere length analysis (STELA) of the X and Y chromosomes in leukocytes of exceptionally old (aged 90-104 years) and younger (aged 23-74 years) individuals. We found that the mean TRFL of 82 exceptionally old individuals was within a range projected by age-dependent TRFL attrition of 99 younger individuals. However, compared with the younger individuals, exceptionally old persons exhibited peaking of the TRFL distribution with overrepresentation of ultra-short telomeres. These findings were confirmed by the STELA. Women had longer mean TRFL than men (6.10 kb vs. 5.86 kb) and exceptionally old women exhibited fewer ultra-short telomeres than exceptionally old men. Our results have implications for gerontological studies of the limitation of lifespan in humans.




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M. Kimura, J. v. B. Hjelmborg, J. P. Gardner, L. Bathum, M. Brimacombe, X. Lu, L. Christiansen, J. W. Vaupel, A. Aviv, and K. Christensen
Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins
Am. J. Epidemiol., April 1, 2008; 167(7): 799 - 806.
[Abstract] [Full Text] [PDF]


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