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Am J Physiol Regul Integr Comp Physiol (March 7, 2002). doi:10.1152/ajpregu.00636.2001
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Articles in PresS, published online ahead of print March 7, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00636.2001
Submitted on October 26, 2001
Accepted on February 20, 2002

The in vivo down-regulation of protein synthesis in the snail Helix apersa during estivation

Julian L Pakay1*, Philip C Withers2, Andrew A Hobbs1, and Michael Guppy1

1 Department of Biochemistry, University of Western Australia, Perth, WA, Australia
2 Department of Zoology, University of Western Australia, Perth, WA, Australia

* To whom correspondence should be addressed. E-mail: jlpakay{at}cyllene.uwa.edu.au.

Protein synthesis is down-regulated during metabolic depression in a number of systems where the metabolic depression is effected by obvious extrinsic cues. The metabolic depression of the estivating land snail Helix apersa occurs in the absence of any obvious physiological stress and has an intrinsic component independent of temperature, pH, oxygen status or osmolality. We show here that this metabolic depression is accompanied by a down-regulation of protein synthesis in vivo. The rate of protein synthesis decreases in two major tissues during estivation to 23% of the awake rate in hepatopancreas and 53% in foot muscle. We show from calculations of the theoretical contribution of protein synthesis to total oxygen consumption that the depression of protein synthesis must be a significant, obligate, in vivo component of metabolic depression in H. aspersa.




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