AJP - Regu AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (December 30, 2003). doi:10.1152/ajpregu.00646.2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
286/6/R1005    most recent
00646.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (30)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reidelberger, R. D
Right arrow Articles by Hulce, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reidelberger, R. D
Right arrow Articles by Hulce, M.
Submitted on November 4, 2003
Accepted on December 25, 2003

Abdominal Vagal Mediation of the Satiety Effects of CCK in Rats

Roger D Reidelberger1*, Jessica Hernandez2, Bernd Fritzsch3, and Martin Hulce4

1 Research, VA-NWIHCS, Omaha, NE, USA; Biomedical Sciences, Creighton University, Omaha, NE, USA
2 Research, VA-NWIHCS, Omaha, NE, USA
3 Biomedical Sciences, Creighton University, Omaha, NE, USA
4 Chemistry, Creighton University, Omaha, NE, USA

* To whom correspondence should be addressed. E-mail: roger.reidelberger{at}med.va.gov.

CCK Type 1 (CCK1) receptor antagonists differing in blood-brain barrier permeability were used to test the hypothesis that satiety is mediated in part by CCK action at CCK1 receptors on vagal sensory nerves innervating the small intestine. Devazepide penetrates the blood-brain barrier; A-70104, the dicyclohexylammonium salt of N{alpha}-3-quinolinoyl-D-Glu-N,N-dipentylamide, does not. At dark onset, non-food-deprived control rats and rats with subdiaphragmatic vagotomies received a bolus injection of devazepide (2.5 µmol/kg iv) or a 3-h infusion of A-70104 (3 µmol kg-1 h-1 iv) either alone or co-administered with a 2-h intragastric infusion of peptone (0.75 or 1 g/h). Food intake was determined from continuous computer recordings of changes in food bowl weight. In control rats both antagonists stimulated food intake and attenuated the anorexic response to intragastric infusion of peptone. In contrast, only devazepide was effective in stimulating food intake in vagotomized rats. Thus, endogenous CCK appears to act both at CCK1 receptors beyond the blood-brain barrier and by a CCK1 receptor-mediated mechanism involving abdominal vagal nerves to inhibit food intake.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Babic, R. L. Townsend, L. M. Patterson, G. M. Sutton, H. Zheng, and H.-R. Berthoud
Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R845 - R854.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
G. M. Holmes, M. Tong, and R. A. Travagli
Effects of brain stem cholecystokinin-8s on gastric tone and esophageal-gastric reflex
Am J Physiol Gastrointest Liver Physiol, March 1, 2009; 296(3): G621 - G631.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. E. Blevins, G. J. Morton, D. L. Williams, D. W. Caldwell, L. S. Bastian, B. E. Wisse, M. W. Schwartz, and D. G. Baskin
Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R476 - R484.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
D. D'Alessio
Intestinal Hormones and Regulation of Satiety: The Case for CCK, GLP-1, PYY, and Apo A-IV
JPEN J Parenter Enteral Nutr, September 1, 2008; 32(5): 567 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. Faipoux, D. Tome, S. Gougis, N. Darcel, and G. Fromentin
Proteins Activate Satiety-Related Neuronal Pathways in the Brainstem and Hypothalamus of Rats
J. Nutr., June 1, 2008; 138(6): 1172 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Wan, F. H. Coleman, and R. A. Travagli
Cholecystokinin-8s excites identified rat pancreatic-projecting vagal motoneurons
Am J Physiol Gastrointest Liver Physiol, August 1, 2007; 293(2): G484 - G492.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Baptista, K. N. Browning, and R. A. Travagli
Effects of cholecystokinin-8s in the nucleus tractus solitarius of vagally deafferented rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1092 - R1100.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
B. C. De Jonghe, A. Hajnal, and M. Covasa
Decreased gastric mechanodetection, but preserved gastric emptying, in CCK-1 receptor-deficient OLETF rats
Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G640 - G649.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
T. H Moran and S. Bi
Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors
Phil Trans R Soc B, July 29, 2006; 361(1471): 1211 - 1218.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Baptista, Z. L. Zheng, F. H. Coleman, R. C. Rogers, and R. A. Travagli
Cholecystokinin Octapeptide Increases Spontaneous Glutamatergic Synaptic Transmission to Neurons of the Nucleus Tractus Solitarius Centralis
J Neurophysiol, October 1, 2005; 94(4): 2763 - 2771.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Stanley, K. Wynne, B. McGowan, and S. Bloom
Hormonal Regulation of Food Intake
Physiol Rev, October 1, 2005; 85(4): 1131 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. L. Powley, M. M. Chi, E. A. Baronowsky, and R. J. Phillips
Gastrointestinal tract innervation of the mouse: afferent regeneration and meal patterning after vagotomy
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R563 - R574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. A. Cupples
Physiological regulation of food intake
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Z. Zheng, M. W. Lewis, and R. A. Travagli
In vitro analysis of the effects of cholecystokinin on rat brain stem motoneurons
Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G1066 - G1073.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. M. Appleyard, T. W. Bailey, M. W. Doyle, Y.-H. Jin, J. L. Smart, M. J. Low, and M. C. Andresen
Proopiomelanocortin Neurons in Nucleus Tractus Solitarius Are Activated by Visceral Afferents: Regulation by Cholecystokinin and Opioids
J. Neurosci., April 6, 2005; 25(14): 3578 - 3585.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. M. Sutton, L. M. Patterson, and H.-R. Berthoud
Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Solitary Nucleus Mediates Cholecystokinin-Induced Suppression of Food Intake in Rats
J. Neurosci., November 10, 2004; 24(45): 10240 - 10247.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. C. Ritter
Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R991 - R993.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.