| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Biology, Georgia State University, Neurobiology and Behavior Program, Center for Behavioral Neuroscience, Atlanta, GA, USA
2 Institute of Normal Human Morphology, University of Ancona, Ancona, Italy
* To whom correspondence should be addressed. E-mail: bartness{at}gsu.edu.
Functional and histological evidence for the sympathetic nervous system (SNS)innervation of white adipose tissue (WAT) exists for several species, but its sensory innervation only has been shown in laboratory rats and its function is unclear. We tested the effects of sensory and SNS innervation of Siberian hamster epididymal and inguinal WAT (EWAT and IWAT) by assessing calcitonin gene-related peptide (CGRP)- and tyrosine hydroxylase (TH)- immunoreactivity (ir), respectively. Next we tested the role of the sensory innervation of WAT on growth and cellularity because WAT surgical denervation increases pad mass via selective increases in fat cell number (FCN) -- an effect ascribed to SNS denervation, but potentially could be due to the inevitable surgically-induced disruption of WAT sensory innervation. Sensory denervation was accomplished via multiple local microinjections of capsaicin into WAT and its effects compared to those of surgical denervation. Surgically-denervated IWAT and EWAT had significantly decreased TH- and CGRP-ir, whereas capsaicin-treated WAT only had significantly decreased CGRP-ir. Surgically-denervated pad masses were significantly increased accompanied by increased total FCN in IWAT, with no change in fat cell size (FCS), whereas EWAT only showed a significant increase in the number of small to medium-sized adipocytes (75-125 µm diameter). By contrast, sensory-denervated pad masses were unchanged, but IWAT had significantly increased average FCS. Collectively, these data provide immunohistochemical evidence for sensory and SNS innervation of WAT in Siberian hamsters and differential control of WAT cellularity by these innervations, as well as the ability of locally applied capsaicin to selectively reduce WAT sensory innervatio
This article has been cited by other articles:
|
|
 |
|
  S. D. Primeaux, M. Tong, and G. M. Holmes Effects of chronic spinal cord injury on body weight and body composition in rats fed a standard chow diet Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1102 - R1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kreier and R. M. Buijs Evidence for parasympathetic innervation of white adipose tissue, clearing up some vagaries Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R548 - R549. [Full Text] [PDF]
|
|
|
|
|
|
A. Giordano, C. Kay Song, R. R. Bowers, J. Christopher Ehlen, A. Frontini, S. Cinti, and T. J. Bartness Reply to Kreier and Buijs: no sympathy for the claim of parasympathetic innervation of white adipose tissue Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R550 - R552. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Shi, A. D. Strader, S. C. Woods, and R. J. Seeley Sexually dimorphic responses to fat loss after caloric restriction or surgical lipectomy Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E316 - E326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Foster and T. J. Bartness Sympathetic but not sensory denervation stimulates white adipocyte proliferation Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1630 - R1637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Giordano, C. K. Song, R. R. Bowers, J. C. Ehlen, A. Frontini, S. Cinti, and T. J. Bartness White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1243 - R1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Lacy and T. J. Bartness Effects of white adipose tissue grafts on total body fat and cellularity are dependent on graft type and location Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R380 - R388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shi and T. J. Bartness White adipose tissue sensory nerve denervation mimics lipectomy-induced compensatory increases in adiposity Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R514 - R520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Rooks, D. M. Penn, E. Kelso, R. R. Bowers, T. J. Bartness, and R. B. S. Harris Sympathetic denervation does not prevent a reduction in fat pad size of rats or mice treated with peripherally administered leptin Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R92 - R102. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
