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Articles in PresS, published online ahead of print January 24, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00651.2001
Submitted on November 2, 2001
Accepted on January 18, 2002
1 Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
* To whom correspondence should be addressed. E-mail: sved{at}bns.pitt.edu.
The present study sought to determine whether arterial baroreceptor afferents mediate the inhibitory effect of an acute increase in AP on thirst stimulated by systemically administered ANG II or by hyperosmolality. Approximately 2 wk after sinoaortic denervation, one of four doses of ANG II (10, 40, 100, or 250 ng/kg/min) was infused intravenously into control and complete sinoaortic denervated (SAD) rats. Complete SAD rats ingested more water and displayed shorter latencies to drink than control rats when infused with 40, 100, or 250 ng/kg/min ANG II. Furthermore, complete SAD rats displayed significantly shorter latencies to drink compared to control rats. In a separate group of rats, drinking behavior was stimulated by increases in plasma osmolality, and mean arterial blood pressure was raised by an infusion of phenylephrine (PE). The infusion of PE significantly reduced water intake and lengthened the latencies to drink in control rats but not in complete SAD rats. In all experiments, drinking behavior of rats that were subjected to sino-aortic denervation surgery but had residual baroreceptor reflex function (partial SAD rats) was similar to that of control rats. Thus, it appears that arterial baroreceptor afferents mediate the inhibitory effect of an acute increase in AP on thirst stimulated by ANG II or hyperosmolality.
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