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Am J Physiol Regul Integr Comp Physiol (July 3, 2003). doi:10.1152/ajpregu.00651.2002
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Submitted on October 22, 2002
Accepted on June 12, 2003

Insulin sensitivity and glucose effectivenes from three minimal models: Effects of energy restriction and body fat in adult male rhesus monkeys

Theresa A Gresl1, Ricki J Colman2, Thomas C Havighurst3, Lauri O Byerley4, David B Allison5, Dale A Schoeller6, and Joseph W Kemnitz7*

1 National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA; Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA
2 National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA
3 Biostatistics and Madical Informatics, University of Wisconsin-Madison, Madison, WI, USA
4 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, WI, USA
5 Biostatistics, University of Alabama-Birmingham, Birmingham, WI, USA
6 Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA
7 National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA; Physiology, University of Wisconsin-Madison, Madison, WI, USA

* To whom correspondence should be addressed. E-mail: kemnitz{at}primate.wisc.edu.

The minimal model of glucose disappearance (MINMOD version 3, MM3) and both the one-compartment (1CMM) and two-compartment (2CMM) minimal models were used to analyze stable isotope-labeled IVGTT data from year 10 of a study of the effect of dietary restriction (DR) in male rhesus monkeys. Adult monkeys (R, n=12) were energy restricted on a semi-purified diet to ~70% of control (ad libitum-fed C, n=12) intake. Under ketamine anesthesia, fasting insulin levels were greater among C monkeys. Insulin sensitivity estimates from all models were greater in R than C monkeys, while glucose effectiveness estimates were not consistently greater in R monkeys. Fasting plasma glucose as well as hepatic glucose production and clearance rates did not differ between groups. Body fat in part statistically mediated the effect of DR to enhance insulin sensitivity indices. Precision of estimation and inter-model relationships among insulin sensitivity and glucose effectiveness estimates were in the ranges of those reported previously for humans and dogs, suggesing that the models may provide valid estimates for rhesus monkeys as well. The observed insulin sensitivity indices from all models, elevated among R vs. C monkeys, may be explained at least in part by the difference in body fat content between these groups after chronic DR.




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