AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (July 3, 2003). doi:10.1152/ajpregu.00651.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/6/R1340    most recent
00651.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gresl, T. A
Right arrow Articles by Kemnitz, J. W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gresl, T. A
Right arrow Articles by Kemnitz, J. W
Submitted on October 22, 2002
Accepted on June 12, 2003

Insulin sensitivity and glucose effectivenes from three minimal models: Effects of energy restriction and body fat in adult male rhesus monkeys

Theresa A Gresl1, Ricki J Colman2, Thomas C Havighurst3, Lauri O Byerley4, David B Allison5, Dale A Schoeller6, and Joseph W Kemnitz7*

1 National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA; Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA
2 National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA
3 Biostatistics and Madical Informatics, University of Wisconsin-Madison, Madison, WI, USA
4 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, WI, USA
5 Biostatistics, University of Alabama-Birmingham, Birmingham, WI, USA
6 Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA
7 National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA; Physiology, University of Wisconsin-Madison, Madison, WI, USA

* To whom correspondence should be addressed. E-mail: kemnitz{at}primate.wisc.edu.

The minimal model of glucose disappearance (MINMOD version 3, MM3) and both the one-compartment (1CMM) and two-compartment (2CMM) minimal models were used to analyze stable isotope-labeled IVGTT data from year 10 of a study of the effect of dietary restriction (DR) in male rhesus monkeys. Adult monkeys (R, n=12) were energy restricted on a semi-purified diet to ~70% of control (ad libitum-fed C, n=12) intake. Under ketamine anesthesia, fasting insulin levels were greater among C monkeys. Insulin sensitivity estimates from all models were greater in R than C monkeys, while glucose effectiveness estimates were not consistently greater in R monkeys. Fasting plasma glucose as well as hepatic glucose production and clearance rates did not differ between groups. Body fat in part statistically mediated the effect of DR to enhance insulin sensitivity indices. Precision of estimation and inter-model relationships among insulin sensitivity and glucose effectiveness estimates were in the ranges of those reported previously for humans and dogs, suggesing that the models may provide valid estimates for rhesus monkeys as well. The observed insulin sensitivity indices from all models, elevated among R vs. C monkeys, may be explained at least in part by the difference in body fat content between these groups after chronic DR.




This article has been cited by other articles:


Home page
 DiabetesHome page
A. O. Chavez, J. C. Lopez-Alvarenga, M. E. Tejero, C. Triplitt, R. A. Bastarrachea, A. Sriwijitkamol, P. Tantiwong, V. S. Voruganti, N. Musi, A. G. Comuzzie, et al.
Physiological and Molecular Determinants of Insulin Action in the Baboon
Diabetes, April 1, 2008; 57(4): 899 - 908.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.