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Am J Physiol Regul Integr Comp Physiol (December 5, 2002). doi:10.1152/ajpregu.00665.2002
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Articles in PresS, published online ahead of print December 5, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00665.2002
Submitted on October 29, 2002
Accepted on December 3, 2002

Separable mechanisms for dorsal hindbrain CART peptide to inhibit gastric emptying and food intake

Ulrika Smedh1* and Timothy H Moran1

1 Department of Psychiatry and Behavioral Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: ulrika.smedh{at}fyfa.ki.se.

We investigated whether dorsal hindbrain and/or peripheral cocaine-and amphetamine-regulated transcript peptide (CARTp) acts to suppress gastric emptying of a caloric stimulus. Further, effects of dorsal hindbrain CARTp on sucrose consumption and licking microstructure was studied, as well as the possible contribution of CRF receptors to mediate effects of CARTp downstream on emptying and sucrose intake. Rats bearing gastric fistulas received intragastric infusions (1.0 ml/min) of 12 ml 12.5% glucose. Gastric samples were withdrawn immediately after the intragastric infusion to reflect emptying during gastric fill. CARTp injected 4th i.c.v. (0.5 and 1.0 µg) suppressed gastric emptying. CARTp reduced sucrose intake at similar doses, and altered a variety of lick microstructural variables (number of licks, bursts, clusters, licks/burst, licks/clusters, interlick interval, first meal size and first meal duration). Pretreatment with the CRF antagonist {alpha}-helical CRF9-41 blocked the effect of 1.0 µg CARTp on gastric emptying, but not on sucrose consumed, or on any of the licking microstructure parameters. These data demonstrate differential mediation of the feeding and gastric inhibitory effects of CARTp and suggest that CARTp-induced inhibition of gastric emptying does not contribute to this peptide's ability to inhibit food intake.




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