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Articles in PresS, published online ahead of print May 6, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00669.2001
Submitted on November 9, 2001
Accepted on April 30, 2002
1 Department of Physiology, University of Greifswald, Greifswald, Germany
2 Department of Clinical Chemistry, University of Greifswald, Greifswald, Germany
3 Department of Pathology, University of Greifswald, Greifswald, Germany
* To whom correspondence should be addressed. E-mail: grisko{at}.uni-greifswald.de.
The effects of neonatal sympathectomy of donors or recipients on post-transplantation arterial pressure were investigated in spontaneously hypertensive rats (SHR) by renal transplantation experiments. Conscious mean arterial pressure (MAP) and renal vascular resistance were 136 ± 1 mmHg and 15.5 ± 1.2 mmHg * min * g * ml-1 in sympathectomized SHR (n = 8) vs. 158 ± 4 mmHg (p < 0.001) and 20.8 ± 1.1 mmHg * min * g * ml-1 (p < 0.05) in controls (n = 10). Seven weeks after transplantation of a kidney from neonatally sympathectomized SHR donors, MAP in SHR recipients (n = 10) was 20 mmHg lower than in controls transplanted with a kidney from hydralazine=treated SHR (n = 10) (p < 0.05) associated with reduced sodium sensitivity of MAP. Neonatal sympathectomy lowered MAP also in F1-hybrids (F1H, SHR x Wistar-Kyoto rats). Within six weeks after transplantation, renal grafts from untreated SHR increased MAP by 20 mmHg in sympathectomized F1H (n = 10) and by 35 mmHg in sham treated F1H (n = 8) (p < 0.05). Neonatal sympathectomy induces chronic changes in SHR kidney function leading to a MAP reduction even when extrarenal sympathetic tone is restored. Generalized reduction in sympathetic tone resets the kidney-fluid system to reduced MAP and blunts the extent of arterial pressure rise induced by an SHR kidney graft.
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