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Am J Physiol Regul Integr Comp Physiol (March 4, 2004). doi:10.1152/ajpregu.00673.2003
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Submitted on November 21, 2003
Accepted on March 2, 2004

Separation of Hepatic and Gastrointestinal Signals from the Common "Hepatic" Branch of the Vagus

Charles C Horn1* and Mark I Friedman1

1 Monell Chemical Senses Center, Philadelphia, PA, USA

* To whom correspondence should be addressed. E-mail: Horn{at}monell.org.

Anatomical studies show that the common hepatic branch (CHB) of the vagus contains afferent fibers that innervate sites outside the hepatoportal region, primarily in the gastrointestinal tract. In the current experiments on the anesthetized rat, the source of signals from the CHB was determined by recording CHB neurophysiological responses before and after transection of the gastroduodenal branch (GDB) of the CHB. Serotonin (5-HT) and CCK-8 were used as probes to stimulate the CHB. Most of the CHB afferent fibers were 5-HT-sensitive (56%), and 35% of these were also sensitive to CCK-8. Portal vein versus jugular vein infusion of 5-HT and CCK-8, and GDB transection, showed that 5-HT and CCK-sensitive fibers innervate the hepatoportal region and areas outside the hepatic hilus (e.g., the gastrointestinal tract). Suppression of basal nerve activity by a 5-HT3 receptor antagonist (Y-25130) suggests that ~50% of CHB afferent fibers contain 5-HT3 receptors, but none of these fibers appear to be in the hepatoportal region since only in rats with an intact GDB did Y-25130 reduce nerve activity. In summary, these data are in close agreement with anatomical observations on the distribution of the CHB fibers and indicate that neurophysiological studies of the CHB must be carefully evaluated given the prominent role of non-hepatoportal afferent signals recorded from the CHB.




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