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Articles in PresS, published online ahead of print May 6, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00683.2001
Submitted on November 16, 2001
Accepted on April 25, 2002
1 Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, USA
* To whom correspondence should be addressed. E-mail: kenny{at}vet.ksu.edu.
Renal and splanchnic sympathetic nerve discharge (SND) responses to increased (38°C- 41°C) internal temperature (Tc) were determined in anesthetized young (3-6 month old), mature (12-month-old) and senescent (24-month-old) Fischer 344 (F344) rats. We hypothesized that SND responses would be altered in senescent and mature rats as demonstrated by attenuated sympathoexcitatory responses to heating and by the absence of hyperthermia-induced SND pattern changes. The following observations were made. 1) Renal and splanchnic SND were significantly increased during heating in young and mature but not in senescent rats. 2) At 41°C; renal and splanchnic SND were higher in young compared with senescent rats and renal SND was higher in mature than senescent rats. 3) Heating changed the SND bursting pattern in young, but not in mature or senescent, rats. 4) SND responses to heating did not differ between baroreceptor-innervated (BRI) and sinoaortic-denervated (SAD) senescent rats but were higher in SAD compared with BRI young rats. These results demonstrate an attenuated responsiveness of sympathetic neural circuits to heating in senescent F344 rats.
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