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Am J Physiol Regul Integr Comp Physiol (December 16, 2004). doi:10.1152/ajpregu.00702.2004
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Submitted on October 13, 2004
Accepted on December 8, 2004

Exercise-induced increase in skeletal muscle vasodilatory responses in Obese Zucker rats

Lusha Xiang1, Jay Naik1, and Robert L Hester1*

1 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA

* To whom correspondence should be addressed. E-mail: rhester{at}physiology.umsmed.edu.

The purpose of this study was to test the hypothesis that exercise training improves microvascular function in obese Zucker rats, a model of obesity and Type II diabetes. Animals were divided into four age-matched groups, lean sedentary (LS), lean exercise (LE), obese sedentary (OS), and obese exercise (OE). The exercise groups were treadmill exercised from 5 to 11 weeks of age, including a 2 weeks acclimation period. Mean arterial pressure (MAP) was not significantly different between any of the groups. The OS had significantly higher mean body weight, blood glucose, insulin, IL-6 and leptin levels compared to the LS, while the OE had significantly lower blood glucose, insulin and IL-6 levels compared to the OS. Functional hyperemia and endothelial-dependent vasodilation were tested in the spinotrapezius muscle using intravital microscopy. Functional hyperemia and acetylcholine (0.1µM, 1µM and 10µM) responses were significantly attenuated in OS compared to the LS, while the contraction and ACh-induced (1µM and 10µM) vasodilation were significantly increased in both LE and OE as compared to the sedentary animals. These results suggest that exercise training can improve vascular function in this model of Type II diabetes. Moreover, the impaired vasodilation observed in 11-week-old OZR suggests that the microvascular dysfunction is not likely due to an elevated blood pressure.




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