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1 Physiology, University of Mississippi Medical Center, Jackson, Mississippi, United States
2 Murrah High School, Jackson, Mississippi, United States
3 Pharmacology, University of Mississippi, University, Mississippi, United States
4 Dept. Pharmacology-University of Mississippi, United States
5 Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States
6 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States
* To whom correspondence should be addressed. E-mail: balexander{at}physiology.umsmed.edu.
Reduced uterine perfusion initiated in late gestation in the rat results in intrauterine growth restriction (IUGR) and development of hypertension by 4 weeks of age. We hypothesize that the renin angiotensin system (RAS), a regulatory system important in the long term control of blood pressure, may be programmed by placental insufficiency and may contribute to the etiology of IUGR hypertension. We previously reported that RAS blockade abolished hypertension in adult IUGR offspring; however, the mechanisms responsible for the early phase of hypertension are unresolved. Therefore, the purpose of this study was to examine RAS involvement in early programmed hypertension and to determine whether temporal changes in RAS expression are observed in IUGR offspring. Renal renin and angiotensinogen mRNA expression were significantly decreased at birth (80 and 60 percent, respectively); plasma and renal RAS did not differ in conjunction with hypertension (mean increase of 14 mmHg) in young IUGR offspring; however, hypertension (mean increase of 22 mmHg) in adult IUGR offspring was associated with marked increases in renal ACE activity (122%) and renal renin and angiotensinogen mRNA (7-fold and 7.4-fold, respectively), but no change in renal angiotensin II or angiotensin type 1 receptor. ACE inhibition (enalapril, 10 mg/kg/day, administered from 2 to 4 weeks of age) abolished hypertension in IUGR at 4 weeks of age (decrease of 15 mmHg, respectively) with no significant depressor effect in control offspring. Therefore, temporal alterations in renal RAS are observed in IUGR offspring and may play a key role in the etiology of IUGR hypertension.
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