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1 Basic Research, Rheoscience, Rodovre, Denmark
2 Basic Research, Rheoscienc, Denmark
* To whom correspondence should be addressed. E-mail: nv{at}rheoscience.com.
The gut hormone peptide YY was recently proposed to comprise an endogenous satiety factor. We have studied acute anorectic functions of PYY3-36 in mice and rats as well as metabolic effects of chronic PYY3-36 administration to diet induced obese mice and rats. A single intraperitoneal injection of PYY3-36 inhibited food intake in mice but not rats. We next investigated the effects of increasing doses (100, 300 and 1000µg/kg/day) of PYY3-36 administered subcutaneously using osmotic mini pumps upon food intake and body-weight in diet-induced obese C57BL/6J mice. Whereas only the highest dose of PYY3-36 (1000µg/kg/day) significantly reduced food intake over the first 3 days, body-weight gain was dose dependently reduced, and at day 28 the group treated with 1000µg/kg/day PYY3-36 weighed approximately 10% less than vehicle treated mice. In addition, mesenteric, epididymal, retroperitoneal and inguinal fat pads were dose dependently reduced. Finally, subcutaneous administration of PYY3-36 (250 and 1000µg/kg/day) for 28 days reduced body-weight and improved glycaemic control in glucose intolerant diet induced obese rats. Neither 250µg/kg nor 1000µg/kg of PYY3-36 were able to elicit a conditioned taste aversion in male rats.
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