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1 Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Center for Neurovisceral Sciences & Women's Health, Los Angeles, California, United States; VA Greater Los Angeles Healthcare System, Los Angeles, California, United States
2 CNS: Center for Neurovisceral Sciences & Women's Health, UCLA Divsion of Digestive Diseases, Los Angeles, California, United States
3 Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Center for Neurovisceral Sciences & Women's Health, Los Angeles, California, United States; David Geffen School of Medicine, University of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, California, United States; VA Greater Los Angeles Healthcare System, Los Angeles, California, United States
4 Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Center for Neurovisceral Sciences & Women's Health, Los Angeles, California, United States; School of Medicine, Universidad Nacional Autonoma de Mexico, Department of Experimental Medicine, Mexico, Mexico
5 Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Center for Neurovisceral Sciences & Women's Health, Los Angeles, California, United States; Hanyang University Medical College, Department of Medicine, Seoul, Korea, Republic of
6 Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Center for Neurovisceral Sciences & Women's Health, Los Angeles, California, United States
* To whom correspondence should be addressed. E-mail: linchang{at}mednet.ucla.edu.
Background: In irritable bowel syndrome (IBS) patients, the relationship between sex and sensitivity to visceral stimuli are incompletely understood. Aim: To evaluate the effect of sex on perceptual responses to visceral stimulation in IBS. Methods: 58 IBS (mean age 42 ± 1 yr; 34 men, 24 women) and 26 healthy controls (mean age 38 ± 3 yr; 9 men, 17 women) underwent barostat-assisted distensions of the rectum and sigmoid colon. Rectal discomfort thresholds were measured using a randomized, phasic distension paradigm before and after repeated noxious sigmoid stimulation (SIG, 60 mmHg pulses). Results: Sex had a significant effect on rectal discomfort thresholds. Women with IBS were the most sensitive (lower thresholds [27 ± 2.7 mmHg] and higher ratings) with significantly lower rectal discomfort thresholds compared to men with IBS (38 ± 2.3 mmHg) and healthy women who were the least sensitive (41.9 ± 3.2 mmHg; both P < 0.01). There were no significant differences in rectal discomfort thresholds between healthy men (34 ± 4.3 mmHg) and men with IBS. Across both IBS and control groups, women demonstrated a significant lowering of discomfort thresholds after noxious sigmoid stimulation P < 0.01), while men did not. Conclusions: Sex significantly influences perceptual sensitivity to rectosigmoid distension. Women show greater perceptual responses to this paradigm.
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