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Am J Physiol Regul Integr Comp Physiol (February 20, 2003). doi:10.1152/ajpregu.00730.2002
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Submitted on December 2, 2002
Accepted on February 18, 2003

Role of angiotensin in body fluid homeostasis of mice: fluid intake, plasma hormones and brain Fos

Neil E Rowland*, Bradley E Goldstein, and Kimberly L Robertson

* To whom correspondence should be addressed. E-mail: nrowland{at}ufl.edu.

CD1 mice injected peripherally with either Ang I or Ang II failed to drink substantial amounts of water or NaCl, yet showed strong Fos immunoreactivity (ir) in subfornical organ (SFO). Mice injected with furosemide showed modest stimulation of NaCl intake either 3 or 24 hr later, were hypovolemic and showed elevated plasma renin activity (PRA). The pattern of Fos-ir in the brain after furosemide was similar to that seen after peripheral injection of Ang II. Mice became hypovolemic following subcutaneous injection of polyethylene glycol (PEG), showed large increases in PRA, aldosterone and water intake, but did not show sodium appetite. PEG-treated mice had strong activation of SFO as well as other brain regions previously shown to be related to Ang-associated drinking in rats. Ang II appears to have a modified role in the behavioral response to fluid loss in mice compared with rats.




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