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Am J Physiol Regul Integr Comp Physiol (July 3, 2003). doi:10.1152/ajpregu.00731.2002
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Submitted on December 2, 2002
Accepted on July 2, 2003

Effects of acetylsalicylic acid treatment on thyroid hormones, prolactins, and the stress response of tilapia (Oreochromis mossambicus)

Rogier D van Anholt1*, Tom Spanings1, William Koven2, and Sjoerd E Wendelaar Bonga1

1 Animal Ecology and Ecophysiology, University of Nijmegen, Nijmegen, The Netherlands
2 Larval Rearing, National Center for Mariculture, Eilat, Israel

* To whom correspondence should be addressed. E-mail: rvanholt{at}sci.kun.nl.

The cyclooxygenase (COX) pathway converts arachidonic acid (ArA) into prostaglandins (PGs), which interact with the stress response in mammals and possibly in fish as well. Acetylsalicylic acid (ASA) is a COX-inhibitor and was used to characterize the effects of PGs on the release of several hormones and the stress response of tilapia (Oreochromis mossambicus). Plasma PGE2 was significantly reduced at 100 mg ASA/kg bw and both basal PGE2 and cotisol levels correlated negatively with plasma salicylate. Basal plasma T3 was reduced by ASA treatment, while PRL188 increased at 100 mg ASA/kg bw. ASA depressed the cortisol response to the mild stress of 5 min net-confinement. As expected, glucose and lactate were elevated in the stressed control fish, but the responses were blunted by ASA treatment. Gill Na+, K+-ATPase activity was not affected by ASA. Plasma osmolarity increased after confinement in all treatments, while sodium only increased at the high ASA dose. This is the first time ASA has been administered to fish in vivo and The altered hormone release and the inhibition of the acute stress response indicated the involvement of PGs in these processes.




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