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Am J Physiol Regul Integr Comp Physiol (March 7, 2002). doi:10.1152/ajpregu.00735.2001
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Articles in PresS, published online ahead of print March 7, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00735.2001
Submitted on December 10, 2001
Accepted on March 1, 2002

Sleep Deprivation Decreases Glycogen in the Cerebellum but not in the Cortex of Young Rats

Phung Gip1*, Grace Hagiwara1, Norman F. Ruby1, and H. Craig Heller1

1 Department of Biological Sciences, Stanford University, Stanford, CA, USA

* To whom correspondence should be addressed. E-mail: pgip{at}stanford.edu.

We tested whether brain glycogen reserves were depleted by sleep deprivation in Long-Evans rats 20-59 days old. Animals were sleep-deprived beginning at lights-on and then immediately sacrificed by microwave irradiation. Glycogen and glucose levels were measured by a fluorescence enzymatic assay. In all age groups, sleep deprivation (SD) reduced cerebellar glycogen levels by an average of 26% after 6 h SD. No changes were observed in the cortex after 6 h SD, but in the oldest animals, 12 h of SD increased cortical glycogen levels. There was a developmental increase in basal glycogen levels in both the cortex and cerebellum that peaked at 34 days and declined thereafter. Robust differences in cortical and cerebellar glycogen levels in response to enforced waking may reflect regional differences in energy utilization and regulation during wake. These results show that brain glycogen reserves are sensitive to sleep deprivation.




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