| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Pharmacological and Physiological Science, Saint Louis University, St. Louis, MO, USA
* To whom correspondence should be addressed. E-mail: taylormm{at}slu.edu.
Intermedin/Adrenomedullin-2 (IMD) is a novel peptide that was independently discovered by two groups. The 47 amino acid peptide is homologous to adrenomedullin (AM) and can activate both the AM and calcitonin gene-related peptide (CGRP) receptors. IMD should, therefore, have actions similar to AM and CGRP. Indeed, like AM and CGRP, intravenous administration of IMD decreased blood pressure in rats and mice. We demonstrate here that immunoreactive IMD is present in plasma as well as heart, lung, stomach, kidney, pituitary and brain. Because IMD is present in brain and both AM and CGRP have potent CNS effects, we examined the ability of IMD within brain to regulate blood pressure and ingestive behaviors. Administration of IMD into the lateral cerebroventricle (i.c.v.) of rats caused significant, long-lasting elevations in mean arterial pressure and heart rate. These elevations are similar to the effects of CGRP and significantly greater than the effects of AM. IMD-induced elevations in mean arterial pressure were inhibited by i.v. administration of phentolamine indicating that IMD activates the sympathetic nervous system. I.c.v administration of IMD also inhibited food and water intake in sated, and in food and water restricted animals. The effects on feeding are likely related to activation of the CGRP receptor and are independent of the effects on water intake, which are likely through the AM receptor. Our data indicate that IMD has potent actions within the CNS that may be a result of the combined activation of both the AM and CGRP receptors.
This article has been cited by other articles:
|
|
 |
|
  W. K. Samson, J. V. Zhang, O. Avsian-Kretchmer, K. Cui, G. L. C. Yosten, C. Klein, R.-M. Lyu, Y. X. Wang, X. Q. Chen, J. Yang, et al. Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions J. Biol. Chem., November 14, 2008; 283(46): 31949 - 31959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. K. Samson, M. M. White, C. Price, and A. V. Ferguson Obestatin acts in brain to inhibit thirst Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R637 - R643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Chauhan, U. Yallampalli, L. Reed, and C. Yallampalli Adrenomedullin 2 Antagonist Infusion to Rats During Midgestation Causes Fetoplacental Growth Restriction Through Apoptosis Biol Reprod, December 1, 2006; 75(6): 940 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Dong, M. M. Taylor, W. K. Samson, and J. Ren Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes J Appl Physiol, September 1, 2006; 101(3): 778 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fujisawa, Y. Nagai, A. Miyatake, K. Miura, T. Shokoji, A. Nishiyama, S. Kimura, and Y. Abe Roles of adrenomedullin 2 in regulating the cardiovascular and sympathetic nervous systems in conscious rats Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1120 - H1127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hashimoto, S. Hyodo, M. Kawasaki, T. Mera, L. Chen, A. Soya, T. Saito, H. Fujihara, T. Higuchi, Y. Takei, et al. Centrally administered adrenomedullin 2 activates hypothalamic oxytocin-secreting neurons, causing elevated plasma oxytocin level in rats Am J Physiol Endocrinol Metab, November 1, 2005; 289(5): E753 - E761. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
