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Am J Physiol Regul Integr Comp Physiol (February 7, 2002). doi:10.1152/ajpregu.00750.2001
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Articles in PresS, published online ahead of print February 7, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00750.2001
Submitted on December 18, 2001
Accepted on February 1, 2002

Spatial and developmental regulation of leptin in fetal sheep

Richard A Ehrhardt, Alan W Bell, and Yves R Boisclair*

* To whom correspondence should be addressed. E-mail: rae2{at}cornell.edu.

To better understand the biology of leptin during prenatal life, the developmental and spatial regulation of leptin was studied in ovine fetuses. Fetal plasma leptin increased steadily between day 40 to 143 post coitus (PC), but was unrelated to fetal weight or placental weight at day 135 PC. Leptin gene expression was detected in fetal brain and liver during most of gestation, and in fetal adipose tissue after day 100 PC. At day 130 PC, expression in fetal perirenal adipose tissue was ~10% of maternal expression. In contrast, leptin gene expression was never detected in the placenta and other uteroplacental tissues. When ewes were fed 55% of requirements between day 122 and 135 PC, fetal plasma leptin remained constant despite acute reduction in maternal concentration. We conclude that fetal plasma leptin originates mostly from non-adipose tissue in early pregnancy and, in addition, from fetal adipose tissue near term. The role of fetal plasma leptin remains uncertain given the lack of nutritional regulation and association with fetal growth.




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