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1 Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
* To whom correspondence should be addressed. E-mail: berthohr{at}pbrc.edu.
Corticolimbic circuits involving the prefrontal cortex, amygdala, and ventral striatum determine the reward value of food and might play a role in environmentally induced obesity. Chemical manipulation of the nucleus accumbens shell (AcbSh) has been shown to elicit robust feeding and Fos expression in the hypothalamus and other brain areas of satiated rats. To determine the neurochemical phenotype of hypothalamic neurons receiving input from the AcbSh, we carried out c-Fos/peptide double-labeling immunohistochemistry in various hypothalamic areas known to contain feeding peptides, from rats that exhibited a significant feeding response after AcbSh microinjection of the GABAA agonist muscimol. In the perifornical area, a significantly higher percentage of orexin neurons expressed Fos after muscimol as compared to saline injection. In contrast, Fos-expression was not induced in MCH and CART neurons. In the arcuate nucleus, Fos activation was significantly lower in neurons co-expressing CART and proopiomelanocortin (POMC), and there was a tendency for higher Fos expression in NPY neurons. In the PVN, no significant activation of oxytocin and CART neurons was found. Thus, AcbSh manipulation may elicit food intake through coordinated stimulation of hypothalamic neurons expressing orexigenic peptides and suppression of neurons expressing anorexigenic peptides. However, activation of many neurons not expressing these peptides suggests that additional peptides/transmitters in the lateral hypothalamus and accumbens projections to other brain areas might also be involved.
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