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Am J Physiol Regul Integr Comp Physiol (January 19, 2006). doi:10.1152/ajpregu.00874.2005
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Submitted on December 14, 2005
Accepted on January 5, 2006

PERSISTANCE OF A BEHAVIORAL FOOD ANTICIPATORY CIRCADIAN RHYTHM FOLLOWING DORSOMEDIAL HYPOTHALAMIC ABLATION IN RATS

G. J Landry1, M. M Simon1, I. C Webb1, and R. E Mistlberger1*

1 Psychology, Simon Fraser University, Burnaby, BC, Canada

* To whom correspondence should be addressed. E-mail: mistlber{at}sfu.ca.

Circadian rhythms of behavior in rodents are regulated by a system of circadian oscillators, including a master light-entrainable pacemaker in the suprachiasmatic nucleus that mediates synchrony to the day-night cycle, and food-entrainable oscillators located elsewhere that generate rhythms of food-anticipatory activity (FAA) synchronized to daily feeding schedules. Despite progress in elucidating neural and molecular mechanisms of circadian oscillators, localization of food-entrainable oscillators driving FAA remains an enduring problem. Recent evidence suggests that the hypothalamic dorsomedial nucleus (DMH) may function as a final common output for behavioral rhythms, and may be critical for the expression of FAA (Saper et al, 2005). To determine whether the reported loss of FAA by DMH lesions is specific to one behavioral measure or generalizes to other measures, rats received large radiofrequency lesions aimed at the DMH, and were recorded in cages with movement sensors. Total and partial DMH ablation was associated with a significant attenuation of LD-entrained activity rhythms during ad-lib food access, due to a selective reduction in nocturnal activity. When food was restricted to a single 3-h daily meal in the middle of the lights-on period, all DMH and intact rats exhibited significant FAA. The rhythm of FAA persisted during a 48 h food deprivation test, and reappeared during a 72 h deprivation test after ad-lib food access. The DMH is not the site of oscillators or entrainment pathways necessary for all manifestations of FAA, but may participate on the output side of this circadian function.




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