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1 A Szent-Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary; Neuroscience Program, Washington State University, Pullman, Washington, USA
2 Neuroscience Program, Washington State University, Pullman, Washington, USA
* To whom correspondence should be addressed. E-mail: krueger{at}vetmed.wsu.edu.
Neuropeptide Y (NPY) is a well-characterized neuromodulator in the central nervous system, primarily implicated in the regulation of feeding. NPY, orexins and ghrelin form a hypothalamic food intake regulatory circuit. Orexin and ghrelin are also implicated in sleep-wake regulation. In the present experiments, we studied the sleep-modulating effects of central administration of NPY in rats. Rats received intracerebroventricular injection of physiological saline or three different doses of NPY (0.4 µg, 2 µg and 10 µg in a volume of 4 µl) at light onset. Another group of rats received bilateral microinjection of saline or 2 µg NPY into the lateral hypothalamus in a volume of 0.2 µl. Sleep-wake activity and motor activity were recorded for 23 hours. Food intake after the control and treatment injections was also measured on separate days. Intracerebroventricular and lateral hypothalamic administration of NPY suppressed non rapid-eye-movement sleep and rapid-eye-movement sleep in rats during the first hour after the injection and also induced changes in EEG delta power spectra. Neuropeptide Y stimulated food intake in the first hour after both routes of administration. Data are consistent with the hypothesis that NPY has a role in the integration of feeding, metabolism and sleep regulation.
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