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Articles in PresS, published online ahead of print November 8, 2001
Am J Physiol Regu Physiol, 10.1152/ajpregu.0527.2001
Submitted on August 31, 2001
Accepted on November 7, 2001
1 Obesity Research, St. Luke's-Roosevelt Hospital, New York, New York, USA; Radiology, Columbia University, New York, New York, USA
2 Obesity Research, St. Luke's-Roosevelt Hospital, New York, New York, USA
3 Radiology, Columbia University, New York, New York, USA
* To whom correspondence should be addressed. E-mail: DG108{at}Columbia.edu.
Magnetic resonance imaging (MRI) has the ability to discriminate between various soft tissues in vivo. The weights of whole body, specific organs, total adipose tissue (TAT), intra-abdominal adipose tissue (IAAT), and skeletal muscle (SM) determined by MRI were compared to weights determined by dissection and chemical analysis in two studies with male Sprague Dawley rats. A 4.2 Tesla MRI machine acquired high-resolution, in-vivo, whole body images of rats longitudinally as they developed obesity or aged. Weights of the whole body and specific tissues were determined using computer image analysis software, including semi-automatic segmentation algorithms for volume calculations. High correlations were found for body weight (r=0.98), TAT (r=0.99) and IAAT (r=0.98) between MRI and dissection/chemical analyses. MRI estimated the weight of brain, kidneys, and spleen with high accuracy (r>0.90), but overestimated IAAT, SM, and liver volumes. No differences were detected in organ weights using MRI and dissection measurements. Longitudinal MRI measurements made during developing obesity and aging accurately represented changes in organ and tissue mass.
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