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Am J Physiol Regul Integr Comp Physiol 283: R197-R204, 2002. First published March 7, 2002; doi:10.1152/ajpregu.00636.2001
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Vol. 283, Issue 1, R197-R204, July 2002

In vivo downregulation of protein synthesis in the snail Helix apersa during estivation

Julian L. Pakay1, Philip C. Withers2, Andrew A. Hobbs1, and Michael Guppy1

1 Biochemistry and 2 Zoology Departments, University of Western Australia, Crawley, Western Australia 6009, Australia

Protein synthesis is downregulated during metabolic depression in a number of systems where the metabolic depression is effected by obvious extrinsic cues. The metabolic depression of the estivating land snail Helix apersa occurs in the absence of any obvious physiological stress and has an intrinsic component independent of temperature, pH, O2 status, or osmolality. We show that this metabolic depression is accompanied by a downregulation of protein synthesis in vivo. The rate of protein synthesis decreases in two major tissues during estivation: to 23% and 53% of the awake rate in hepatopancreas and foot muscle, respectively. We show from calculations of the theoretical contribution of protein synthesis to total O2 consumption that the depression of protein synthesis must be a significant, obligate, in vivo component of metabolic depression in H. aspersa.

pulmonate snail; metabolic depression; mollusc


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