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Am J Physiol Regul Integr Comp Physiol 283: R843-R852, 2002. First published June 20, 2002; doi:10.1152/ajpregu.00054.2002
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Vol. 283, Issue 4, R843-R852, October 2002

Chemical activation of C1-C2 spinal neurons modulates activity of thoracic respiratory interneurons in rats

C. Qin, J. P. Farber, M. J. Chandler, and R. D. Foreman

Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190

Discharge patterns of thoracic dorsal horn neurons are influenced by chemical activation of cell bodies in cervical spinal segments C1-C2. The present aim was to examine whether such activation would specifically affect thoracic respiratory interneurons (TRINs) of the deep dorsal horn and intermediate zone in pentobarbital sodium-anesthetized, paralyzed, artificially ventilated rats. We also characterized discharge patterns and pathways of TRIN activation in rats. A total of 77 cells were classified as TRINs by location, continued burst activity related to phrenic discharge when the respirator was stopped, and lack of antidromic response from selected pathways. A variety of respiration-phased discharge patterns was documented whose pathways were interrupted by ipsilateral C1 transection. Glutamate pledgets (1 M, 1 min) on the dorsal surface of the spinal cord inhibited 22/49, excited 15/49, or excited/inhibited 3/49 tested cells. Incidence of responses did not depend on whether the phase of TRIN discharge was inspiratory, expiratory, or biphasic. Phrenic nerve activity was unaffected by chemical activation of C1-C2 in this preparation. Besides supraspinal input, TRIN activity may be influenced by upper cervical modulatory pathways.

propriospinal; glutamate; cervical spinal cord; thoracic spinal cord; respiration.


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