AJP - Regu Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 283: R1087-R1093, 2002. First published August 1, 2002; doi:10.1152/ajpregu.00402.2002
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/R1087    most recent
00402.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Levin, B. E.
Right arrow Articles by Dunn-Meynell, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levin, B. E.
Right arrow Articles by Dunn-Meynell, A. A.
Vol. 283, Issue 5, R1087-R1093, November 2002

Maternal obesity alters adiposity and monoamine function in genetically predisposed offspring

Barry E. Levin and Ambrose A. Dunn-Meynell

Neurology Service, Veterans Affairs Medical Center, East Orange 07018; and Department of Neurosciences, New Jersey Medical School, Newark, New Jersey 07103

The impact of maternal obesity on brain monoamine function in adult offspring of dams selectively bred to express diet-induced obesity (DIO) or diet resistance (DR) was assessed by making dams obese or lean during gestation and lactation. After 12 wk on chow and 4 wk on a 31% fat diet, offspring hypothalamic nucleus size and [3H]nisoxetine binding to norepinephrine transporters (NET) and [3H]paroxetine binding to serotonin transporters (SET) were measured. Offspring of obese DIO dams became more obese than all other groups, but maternal obesity did not alter weight gain in DR offspring (25). Maternal obesity was associated with 10-17% enlargement of ventromedial nuclei (VMN) and dorsomedial nuclei in both DIO and DR offspring. Offspring of obese DIO dams had 25-88% lower NET binding in the paraventricular nuclei (PVN), arcuate nuclei, VMN, and the central amygdalar nuclei, while offspring of obese DR dams had 43-67% higher PVN and 90% lower VMN NET binding and a generalized increase in SET binding across all hypothalamic areas compared with other groups. Thus maternal obesity was associated with alterations in offspring brain monoamine metabolism, which varied as a function of genotype and the development of offspring obesity.

diet-induced obesity; norepinephrine; serotonin; hypothalamus; amygdala; neural plasticity; insulin; leptin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Le Foll, B. G. Irani, C. Magnan, A. Dunn-Meynell, and B. E. Levin
Effects of maternal genotype and diet on offspring glucose and fatty acid-sensing ventromedial hypothalamic nucleus neurons
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2009; 297(5): R1351 - R1357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. G. Irani, C. Le Foll, A. A. Dunn-Meynell, and B. E. Levin
Ventromedial nucleus neurons are less sensitive to leptin excitation in rats bred to develop diet-induced obesity
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R521 - R527.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. M. Patterson, S. G. Bouret, A. A. Dunn-Meynell, and B. E. Levin
Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R537 - R548.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. E. Levin
Why some of us get fat and what we can do about it
J. Physiol., September 1, 2007; 583(2): 425 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. N. Gorski, A. A. Dunn-Meynell, and B. E. Levin
Maternal obesity increases hypothalamic leptin receptor expression and sensitivity in juvenile obesity-prone rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1782 - R1791.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. N. Gorski, A. A. Dunn-Meynell, T. G. Hartman, and B. E. Levin
Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R768 - R778.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. E. Levin, C. Magnan, S. Migrenne, S. C. Chua Jr., and A. A. Dunn-Meynell
F-DIO obesity-prone rat is insulin resistant before obesity onset
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R704 - R711.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. L. White, H. D. Braymer, D. A. York, and G. A. Bray
Effect of a high or low ambient perinatal temperature on adult obesity in Osborne-Mendel and S5B/Pl rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1376 - R1384.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. E. Levin
The drive to regain is mainly in the brain
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1297 - R1300.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online